Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines.

British journal of pharmacology ·Vol. 42 ·No. 2 ·1971-06-00 ·Pages 305-7

Camargo A, Ferreira SH

Abstract

BPF and BAL inhibited kininase activity of homogenates of rat intestine. However, BFP potentiated and BAL inhibited the contractions induced by bradykinin on rat isolated duodenum (low calcium solution) and terminal ileum (normal calcium solution). Neither BPF nor BAL affects the relaxation induced by bradykinin of rat duodenum bathed in normal Tyrode. These results suggest that two different types of pharmacological receptor are involved in the action of bradykinin on rat intestine, and that other factors besides the inhibition of agonist destruction participate in the mechanism of potentiation of kinin action by BPF.

MeSH Terms

Animals Bradykinin/pharmacology Depression, Chemical Dimercaprol/pharmacology Duodenum/drug effects,enzymology Ileum/drug effects,enzymology In Vitro Techniques Muscle Contraction/drug effects Muscle, Smooth/drug effects Peptides/pharmacology Rats Receptors, Drug

Chemicals

Peptides Receptors, Drug Dimercaprol Bradykinin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Camargo A

Ferreira S H

References (12)

12 references, click to expand

Potentiation of some bradykinin effects by thiol compounds.
Br J Pharmacol Chemother. 1965 Oct;25(2):405-10 PMID: 5866720
Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) from Bothrops jararaca venom.
Experientia. 1965 Jun 15;21(6):347-9 PMID: 5870517
The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat.
Br J Pharmacol Chemother. 1967 Jun;30(2):417-24 PMID: 6036419
On the potentiation of kinins by sulfhydrylic compounds.
Arch Int Pharmacodyn Ther. 1967 Jul;168(1):188-98 PMID: 4292761
The relaxing effect of bradykinin on intestinal smooth muscle.
Br J Pharmacol Chemother. 1968 Jan;32(1):78-86 PMID: 5640177
Inactivation of bradykinin in the pulmonary circulation.
Biochem J. 1968 Dec;110(4):795-7 PMID: 5704826
Cardiovascular and gastrointestinal effects of bradykinin and its potentiation by thiols in rats.
J Pharm Sci. 1969 Aug;58(8):971-5 PMID: 5344532
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.
Biochemistry. 1970 Jun 23;9(13):2583-93 PMID: 4317874
The extraction of human urinary kinin (substance Z) and its relation to the plasma kinins.
Br J Pharmacol Chemother. 1959 Mar;14(1):117-24 PMID: 13651588
Allosteric proteins and cellular control systems.
J Mol Biol. 1963 Apr;6:306-29 PMID: 13936070
Potentiation of bradykinin by dimercaptopropanol (bal) and other inhibitors of its destroying enzyme in plasma.
Biochem Pharmacol. 1962 Dec;11:1123-8 PMID: 13944892
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.
Br J Pharmacol Chemother. 1965 Feb;24:163-9 PMID: 14302350

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1971.tb07113.x

Published

1971-06-00

Pages

305-7

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1667156

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1971.tb07113.x PMC Full Text View journal details

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Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines.

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