Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.

Journal of bacteriology ·Vol. 106 ·No. 1 ·1971-04-00 ·Pages 227-37

Rothman-Denes L, Martin RG

Abstract

Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.

MeSH Terms

Amino Acids/pharmacology Aspartic Acid/metabolism,pharmacology Chromosome Mapping Culture Media Drug Resistance, Microbial Enzyme Repression Genes Genetics, Microbial Histidine/metabolism,pharmacology Microbial Sensitivity Tests Models, Theoretical Molecular Biology Mutation Operon Paper Phosphotransferases/antagonists & inhibitors,metabolism Recombination, Genetic Salmonella typhimurium/drug effects,enzymology,growth & development,isolation & purification,metabolism Spectrophotometry Transduction, Genetic Triazoles

Chemicals

Amino Acids Culture Media Triazoles Aspartic Acid Histidine Phosphotransferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rothman-Denes L

Martin R G

References (24)

24 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.106.1.227-237.1971

Published

1971-04-00

Pages

227-37

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC248666

Subset

External Links

PubMed source DOI: 10.1128/jb.106.1.227-237.1971 PMC Full Text View journal details

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Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.

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