Endotoxin and acute renal failure associated with obstructive jaundice.

British medical journal ·Vol. 4 ·No. 5733 ·1970-11-21 ·Pages 472-4

Wardle EN, Wright NA

Abstract

A single dose of endotoxin given to rats with obstructive jaundice produced death with intravascular coagulation. This action was apparently due to delayed clearance of endotoxin from the circulation. The finding is relevant to "hepatorenal failure," which can be caused by bacteraemia after biliary tract operations.

MeSH Terms

Acute Kidney Injury/chemically induced Animals Blood Coagulation Tests Blood Platelets Cholestasis/complications Endotoxins Escherichia coli Fibrin Fibrinogen Kidney Diseases/physiopathology Liver Diseases/physiopathology Prothrombin Time Rats Thrombelastography Thrombin

Chemicals

Endotoxins Fibrin Fibrinogen Thrombin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wardle E N

Wright N A

References (27)

27 references, click to expand

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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.4.5733.472

Published

1970-11-21

Pages

472-4

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1820084

Subset

External Links

PubMed source DOI: 10.1136/bmj.4.5733.472 PMC Full Text

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Endotoxin and acute renal failure associated with obstructive jaundice.

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