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PMID: 14463528 Published · ppublish English Journal Article

Reticuloendothelial clearance of circulating fibrin in the pathogenesis of the generalized Shwartzman reaction.

The Journal of experimental medicine ·Vol. 115 ·1962-05-01 ·Pages 1065-82

LEE L

Abstract

Intravenous injections of endotoxin or infusions of thrombin in the rabbit initiate intravascular coagulation but do not usually result in massive deposition of fibrin. It has been proposed that the reticuloendothelial system may function efficiently in the removal of circulating fibrin; its blockade permits reproduction of all of the features of the generalized Shwartzman reaction by infusions of thrombin. In the rabbit the reticuloendothelial system may constitute the major protective mechanism against the vasculo-occlusive lesions of the generalized Shwartzman reaction, which appears to be the direct consequence of intravascular fibrin formation and deposition.

Keywords
ALLERGY/experimental ANTICOAGULANTS/pharmacology FIBRIN/metabolism KIDNEY/blood supply RETICULOENDOTHELIAL SYSTEM/physiology
MeSH Terms
Animals Anticoagulants/pharmacology Endotoxins Fibrin/metabolism Humans Hypersensitivity Immune System Diseases Kidney/blood supply Mononuclear Phagocyte System/physiology Rabbits Shwartzman Phenomenon Thrombin
Chemicals
Anticoagulants Endotoxins Fibrin Thrombin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
LEE L
References (27)
27 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.115.5.1065
Published
1962-05-01
Pages
1065-82
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137542
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.115.5.1065 PMC Full Text View journal details
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