Home LiteratureArticle Details
PMID: 4903002 Published · ppublish ger Journal Article Review

[Regulation of cholesterol synthesis].

Regulation der Cholesterol-Synthese.

Die Naturwissenschaften ·Vol. 56 ·No. 8 ·1969-08-00 ·Pages 398-405

Hamprecht B

Abstract

暂无摘要

MeSH Terms
Acetates/metabolism Animals Bile Acids and Salts/metabolism Cholesterol/biosynthesis Cholestyramine Resin Circadian Rhythm Coenzyme A Hunger Mevalonic Acid/metabolism Microsomes, Liver/metabolism Norepinephrine/pharmacology Oxidoreductases/metabolism Rats Thyroid Hormones/pharmacology Tryptophan/metabolism
Chemicals
Acetates Bile Acids and Salts Thyroid Hormones Cholestyramine Resin Tryptophan Cholesterol Oxidoreductases Mevalonic Acid Coenzyme A Norepinephrine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hamprecht B
References (107)
107 references, click to expand
  1. Induction of tyrosine-alpha-ketoglutarate transaminase in rat liver. IV. Evidence for an increase in the rate of enzyme synthesis.
    J Biol Chem. 1962 Nov;237:3495-8 PMID: 14031971
  2. INDUCTION OF SEVERAL ADAPTIVE ENZYMES BY ACTINOMYCIN D.
    Science. 1964 Oct 30;146(3644):661-3 PMID: 14191708
  3. The inhibition of sterol biosynthesis in rat liver homogenates by bile.
    J Biol Chem. 1966 Oct 25;241(20):4722-30 PMID: 5926178
  4. Studies on the feed-back regulation of cholesterol synthesis.
    Adv Enzyme Regul. 1964;2:249-64 PMID: 4285958
  5. Suppression of hepatic cholesterol synthesis in the rat by cholesterol feeding.
    J Biol Chem. 1954 Jan;206(1):465-9 PMID: 13130569
  6. Daily rhythmic changes in tyrosine transaminase activity of the rat liver.
    Proc Natl Acad Sci U S A. 1967 Jun;57(6):1594-8 PMID: 4382380
  7. The role of the liver in the turnover of plasma cholesterol.
    Arch Biochem Biophys. 1955 May;56(1):28-37 PMID: 14377547
  8. INTESTINAL PHOSPHATASE ACTIVITY: ACCELERATION OF INCREASE BY PUROMYCIN AND ACTINOMYCIN.
    Science. 1964 Apr 24;144(3617):414-6 PMID: 14169330
  9. Effect of dietary cholic acid on in vivo cholesterol metabolism.
    Proc Soc Exp Biol Med. 1959 Jan;100(1):3-6 PMID: 13634014
  10. The influence of thyroid hormones on beta-hydroxy-beta-methylglutaryl-coenzyme A reductase of rat liver.
    Eur J Biochem. 1968 Apr 3;4(2):273-8 PMID: 5655502
  11. Effects of bile salts on intermediate metabolism of the intestinal mucosa.
    Fed Proc. 1967 Nov-Dec;26(6):1589-98 PMID: 6075902
  12. Translational control of gene expression.
    Cold Spring Harb Symp Quant Biol. 1966;31:321-33 PMID: 5237193
  13. Fat feeding and cholesterol synthesis.
    Biochim Biophys Acta. 1967 Jun 6;137(3):533-9 PMID: 6049948
  14. Genetic regulatory mechanisms in the synthesis of proteins.
    J Mol Biol. 1961 Jun;3:318-56 PMID: 13718526
  15. EFFECT OF ENDOGENOUS AND EXOGENOUS CHOLESTEROL ON THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS.
    J Clin Invest. 1963 Sep;42:1521-8 PMID: 14060995
  16. Systematic oscillations in metabolic activity in rat liver and in hepatomas. I. Morris hepatoma No. 7793.
    Cancer Res. 1966 Jul;26(7):1547-60 PMID: 4287850
  17. EFFECT OF CHOLESTYRAMINE, A BILE ACID-BINDING POLYMER ON PLASMA CHOLESTEROL AND FECAL BILE ACID EXCRETION IN THE RAT.
    Proc Soc Exp Biol Med. 1963 Nov;114:352-5 PMID: 14101187
  18. Effect of cholesterol in suspension on the incorporation of phosphate into phospholipid by macrophages in vitro.
    J Lipid Res. 1966 Jan;7(1):132-40 PMID: 4284741
  19. beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
    Biochim Biophys Acta. 1960 Jun 3;40:491-501 PMID: 13805544
  20. Intestinal sterols. III. Effects of age, sex and diet.
    Arch Biochem Biophys. 1957 Jan;66(1):226-33 PMID: 13395542
  21. Enzyme levels in rats adapted to 36-hour fasting.
    Adv Enzyme Regul. 1966;4:247-65 PMID: 4383521
  22. Influence of turnover rates on the responses of enzymes to cortisone.
    Mol Pharmacol. 1965 Sep;1(2):149-56 PMID: 4378655
  23. Suppression of the daily rhythm in tyrosine transaminase activity by acute elevation of norepinephrine.
    Nature. 1968 Oct 12;220(5163):161-2 PMID: 4386721
  24. Sites of control of hepatic cholesterol biosynthesis.
    J Lipid Res. 1966 Sep;7(5):698-707 PMID: 5971049
  25. The effect of bile acids on cholesterol absorption, deposition and synthesis in the rat. Cholesterol studies. V.
    Acta Physiol Scand. 1955 Oct 27;34(2-3):206-17 PMID: 13282729
  26. Effects of conjugated bile acids on in vivo cholesterol metabolism in the mouse.
    Proc Soc Exp Biol Med. 1961 May;107:49-51 PMID: 13688686
  27. AN INTERACTION OF DEOXYCHOLATE WITH A MICROSOMAL COMPONENT.
    Biochem Biophys Res Commun. 1963 Aug 1;12:320-3 PMID: 14070337
  28. THE BIOSYNTHESIS OF MEVALONIC ACID.
    Proc Natl Acad Sci U S A. 1959 Apr;45(4):499-504 PMID: 16590405
  29. Cholesterol biosynthesis in preparations of liver from normal, fasting, x-irradiated, cholesterol-fed, triton, or delta 4-cholesten-3-one-treated rats.
    J Biol Chem. 1959 Feb;234(2):262-7 PMID: 13630891
  30. Effect of cholestyramine on cholesterol metabolism in young adult swine.
    Proc Soc Exp Biol Med. 1966 Apr;121(4):1244-8 PMID: 5937736
  31. The quantitative regulation of specific proteins in animal tissues; words and facts.
    Enzymol Biol Clin (Basel). 1967;8(2):81-96 PMID: 4382227
  32. Increased cholesterol biosynthesis following phenobarbital induced hypertrophy of agranular endoplasmic reticulum in liver.
    Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1136-9 PMID: 5836022
  33. [On beta-hydroxy-beta-methylglutaryl reductase of yeast. On the biosynthesis of terpene. IX].
    Biochem Z. 1959;332:195-213 PMID: 14410069
  34. THE DIFFERENTIAL EFFECT OF ACTINOMYCIN D ON THE BIOSYNTHESIS OF ENZYMES IN BACILLUS SUBTILIS AND BACILLUS CEREUS.
    Biochim Biophys Acta. 1963 Sep 17;76:80-93 PMID: 14068563
  35. The effect of cholesterol feeding and fasting upon beta-hydroxy-beta-methylglutaryl coenzyme A reductase.
    J Biol Chem. 1967 Mar 10;242(5):990-3 PMID: 6020446
  36. Idiopathic hypercholesterolemia: demonstration of an impaired feedback control of cholesterol synthesis in vivo.
    Tohoku J Exp Med. 1965 Nov 25;87(2):155-67 PMID: 5893476
  37. EFFECT OF PHYSICAL ACTIVITY UPON CHOLESTEROL SYNTHESIS IN THE RAT LIVER.
    J Atheroscler Res. 1964 Jul-Aug;4:351-5 PMID: 14193823
  38. EVIDENCE FOR A CONTRIBUTION BY THE INTESTINAL WALL TO THE SERUM CHOLESTEROL OF THE RAT.
    J Lipid Res. 1965 Apr;6:173-81 PMID: 14328424
  39. Systematic oscillations in metabolic functions in liver from rats adapted to controlled feeding schedules.
    Fed Proc. 1968 Sep-Oct;27(5):1238-45 PMID: 4386257
  40. Cholesterol synthesis by liver. III. Its regulation by ingested cholesterol.
    J Biol Chem. 1953 Mar;201(1):137-41 PMID: 13044782
  41. Regulation of liver cholesterol synthesis by lymph cholesterol.
    Science. 1957 Jun 14;125(3259):1194-5 PMID: 13432781
  42. Control of cholesterol biosynthesis by a plasma apo-lipoprotein.
    Nature. 1969 Feb 8;221(5180):574-5 PMID: 5789314
  43. Bile acids in portal blood of fats fed different diets and cholestyramine. Bile acids and steroids 189.
    Eur J Biochem. 1967 Nov;2(4):375-83 PMID: 6080771
  44. C14-Cholesterol. V. Obligatory function of bile in intestinal absorption of cholesterol.
    J Biol Chem. 1952 Sep;198(1):111-4 PMID: 12999722
  45. FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS IN MAN.
    J Clin Invest. 1963 Oct;42:1613-8 PMID: 14074355
  46. Regulation of protein turnover in mammalian tissues.
    Fed Proc. 1968 Sep-Oct;27(5):1223-30 PMID: 5673273
  47. Role of amino acid supply in regulating ribosome function.
    Fed Proc. 1968 Sep-Oct;27(5):1231-7 PMID: 4876910
  48. The effect of fasting upon tissue lipogenesis in the intact rat.
    J Biol Chem. 1954 May;208(1):115-22 PMID: 13174520
  49. The effect of feeding with a tryptophan-free amino acid mixture on rat-liver polysomes and ribosomal ribonucleic acid.
    Biochem J. 1966 Nov;101(2):417-28 PMID: 5966279
  50. Control of RNA synthesis in Escherichia coli. I. Amino acid dependence of the synthesis of the substrates of RNA polymerase.
    J Mol Biol. 1968 Jul 14;34(2):317-30 PMID: 4938549
  51. Studies on bile acids. Some observations on the intracellular localization of major bile acids in rat liver.
    Biochemistry. 1966 Nov;5(11):3662-8 PMID: 5972346
  52. [Effect of glucagon on lipid biosynthesis in rat liver].
    Pol Arch Med Wewn. 1967;39(1):67-71 PMID: 6052313
  53. Excretion of bile acids and beta-hydroxysterols by rats.
    Arch Biochem Biophys. 1958 Aug;76(2):367-76 PMID: 13572022
  54. Translation-level control of protein synthesis during early development.
    Biochem Biophys Res Commun. 1965 Dec 21;21(6):595-600 PMID: 5879468
  55. The species specificity of cholestyramine in its effect on synthesis of liver lipids and level of serum cholesterol.
    Proc Soc Exp Biol Med. 1966 Jun;122(2):328-34 PMID: 5980531
  56. Cholesterol synthesis by liver. I. Influence of fasting and of diet.
    J Biol Chem. 1952 May;196(2):569-73 PMID: 12981000
  57. TRANSAMIDINASE ACTIVITY IN MOUSE KIDNEY--AN ASPECT OF CIRCADIAN PERIODIC ENZYME ACTIVITY.
    Ann N Y Acad Sci. 1964 Sep 10;117:337-53 PMID: 14198675
  58. Mechanism of the paradoxical stimulation of ribonuclease synthesis in Bacillus subtilis by actinomycin D.
    Biochim Biophys Acta. 1968 Nov 20;169(1):260-2 PMID: 4973247
  59. Studies on the site of the feedback control of cholesterol synthesis.
    J Clin Invest. 1960 Apr;39:642-52 PMID: 14447167
  60. The effect of some dietary additions on the synthesis of cholesterol from acetate in vitro.
    J Biol Chem. 1953 May;202(1):77-81 PMID: 13061433
  61. Cholesterol synthesis by the gastrointestinal tract: localization and mechanisms of control.
    J Clin Invest. 1965 Aug;44(8):1311-27 PMID: 5835437
  62. Apparent non-specific effect of bile salts on the terminal reactions of cholesterol biosynthesis by rat liver.
    Biochim Biophys Acta. 1967 Apr 4;137(2):400-2 PMID: 6058813
  63. REGULATION OF XANTHINE DEHYDROGENASE IN CHICK LIVER. EFFECT OF STARVATION AND OF ADMINISTRATION OF PURINES AND PURINE NUCLEOSIDES.
    Biochem J. 1965 Feb;94:309-13 PMID: 14348191
  64. The half-life-time of induced tryptophan peroxidase in vivo.
    Arch Biochem Biophys. 1959 Dec;85:478-82 PMID: 13821912
  65. Discovery and chemistry of mevalonic acid.
    Adv Enzymol Relat Subj Biochem. 1961;23:471-83 PMID: 14004324
  66. Effect of dietary bile acids on in vivo cholesterol metabolism in the rat.
    Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):892-4 PMID: 13591378
  67. Thyroid hormones and the formation and distribution of ribosomes.
    Acta Endocrinol (Copenh). 1968;:Suppl 124:141+ PMID: 4868637
  68. CHOLESTEROL BIOSYNTHESIS: MEVALONATE SYNTHESIS INHIBITED BY BILE SALTS.
    Science. 1965 Feb 26;147(3661):1038 PMID: 14245778
  69. Circadian rhythm for tryptophan pyrrolase activity and its circulating substrate.
    Science. 1966 Sep 30;153(3744):1642-4 PMID: 5917076
  70. Circadian rhythms of liver enzymes and their relationship to enzyme induction.
    Science. 1967 Sep 29;157(3796):1563-4 PMID: 4382575
  71. ESTRONE INHIBITION OF CHOLESTEROL BIOSYNTHESIS AT THE MEVALONIC ACID STAGE.
    Science. 1964 Apr 17;144(3616):301-2 PMID: 14169718
  72. Cholesterol synthesis by liver. II. Effect of hypophysectomy.
    J Biol Chem. 1952 Dec;199(2):543-5 PMID: 13022659
  73. Regulation of cholesterol metabolism by thyroid hormone. The relation between thyroid hormone and the feedback mechanism of cholesterol metabolism.
    Sci Sin. 1965 Jun;14(6):874-84 PMID: 5826808
  74. Influence of the thyroid on the synthesis of cholesterol by liver and skin in vitro.
    J Physiol. 1958 Dec 4;144(2):361-72 PMID: 13611699
  75. Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.
    Eur J Biochem. 1967 Jul;2(1):44-9 PMID: 6079762
  76. A PARADOXICAL EFFECT OF ACTINOMYCIN D: THE MECHANISM OF REGULATION OF ENZYME SYNTHESIS BY HYDROCORTISONE.
    Proc Natl Acad Sci U S A. 1964 Oct;52:1121-9 PMID: 14224391
  77. Stimulation of liver cholesterol synthesis by actinomycin D.
    Biochem J. 1968 Oct;109(5):775-85 PMID: 5696865
  78. Turnover of constituents of the endoplasmic reticulum membranes of rat hepatocytes.
    J Biol Chem. 1967 May 25;242(10):2389-96 PMID: 4381697
  79. The biosynthesis of cholesterol.
    Adv Enzymol Relat Subj Biochem. 1960;22:281-335 PMID: 13737102
  80. Dynamics of cholesterol metabolism. I. Factors regulating total sterol biosynthesis and accumulation in the rat.
    Proc Natl Acad Sci U S A. 1963 Jul;50:117-24 PMID: 13971791
  81. [On the function of deoxyribonucleic acids and the theory of the regulation of gene action].
    Naturwissenschaften. 1967 Aug;54(15):389-96 PMID: 5591526
  82. Circadian oscillation in rat liver tryptophan pyrrolase and its analysis by substrate and hormone induction.
    Nature. 1968 Aug 10;219(5154):619-21 PMID: 5665713
  83. Inhibition of cholesterol formation by rat liver homogenates.
    Can J Biochem Physiol. 1955 Mar;33(2):135-8 PMID: 14352019
  84. Noradrenalin-induced increase in hepatic cholesterol synthesis and its blockade by puromycin.
    Biochim Biophys Acta. 1968 May 1;152(3):619-26 PMID: 5656828
  85. Acceleration of hepatic cholesterol synthesis by triton WR-1339.
    J Exp Med. 1955 Mar 1;101(3):225-32 PMID: 13233448
  86. Feedback control of cholesterol biosynthesis in the mouse.
    Proc Soc Exp Biol Med. 1962 Apr;109:863-8 PMID: 13866579
  87. Epinephrine and cholesterol metabolism in the dog. Hepatic metabolism of pyruvate and mevalonate in vitro.
    J Pharmacol Exp Ther. 1966 Jan;151(1):151-7 PMID: 5902173
  88. EFFECT OF CYCLOHEXIMIDE ON RIBOSOMAL AGGREGATES ENGAGED IN PROTEIN SYNTHESIS IN VITRO.
    Biochim Biophys Acta. 1964 Jul 22;87:525-8 PMID: 14211653
  89. CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.
    Science. 1964 Dec 11;146(3650):1474-6 PMID: 14208575
  90. THE IMPORTANCE OF BOTH SYNTHESIS AND DEGRADATION IN THE CONTROL OF ARGINASE LEVELS IN RAT LIVER.
    J Biol Chem. 1964 Nov;239:3808-17 PMID: 14257612
  91. Studies on the roles of synthesis and degradation in the control of enzyme levels in animal tissues.
    Bull Soc Chim Biol (Paris). 1966;48(10):1009-30 PMID: 4959571
  92. Action of some effectors on the hydrolysis of long-chain triglycerides by pancreatic lipase.
    Biochim Biophys Acta. 1968 Sep 2;164(1):47-58 PMID: 5680295
  93. The Framingham study: a prospective study of coronary heart disease.
    Fed Proc. 1962 Jul-Aug;21(4)Pt 2:52-7 PMID: 14453051
  94. Regulation of polysome aggregation in a cell-free system through amino acid supply.
    J Mol Biol. 1968 Jul 14;34(2):199-218 PMID: 5760456
  95. Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes.
    Biochim Biophys Acta. 1968 Oct 22;164(2):357-68 PMID: 5721032
  96. Polysomes on a nuclear membrane fraction as intermediates in the transfer of ribonucleic acid from the nucleus to the cytoplasm.
    Nature. 1966 Feb 26;209(5026):893-5 PMID: 5922780
  97. Cholesterol metabolism. I. Effect of dietary cholesterol on the synthesis of cholesterol in dog tissue in vitro.
    J Biol Chem. 1953 Apr;201(2):519-28 PMID: 13061387
  98. Plasma cholesterol lowering action of bile acid binding polymers in experimental animals.
    J Lipid Res. 1960 Oct;1:469-73 PMID: 13775898
  99. The biosynthesis of cholesterol from acetate-1-C14 by cellular fractions of rat liver.
    J Biol Chem. 1956 Sep;222(1):1-15 PMID: 13366974
  100. The effect of fasting upon lipogenesis in the intact rat.
    J Biol Chem. 1952 May;196(1):389-94 PMID: 12980979
  101. The paradoxical effect of hydrocortisone and actinomycin on the activity of rabbit leucocyte alkaline phosphatase.
    Biochem Biophys Res Commun. 1967 Feb 8;26(3):265-71 PMID: 6034351
  102. The effect of ligation of the common bile duct on cholesterol synthesis in the rat.
    J Exp Med. 1954 Jan 1;99(1):43-53 PMID: 13118062
  103. Feedback control of mevalonate synthesis by dietary cholesterol.
    J Biol Chem. 1966 Feb 10;241(3):602-9 PMID: 5908125
  104. Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat.
    J Lipid Res. 1967 Mar;8(2):97-104 PMID: 14564715
  105. On the regulation of bile acid formation in the rat liver.
    Acta Physiol Scand. 1958 Jul 17;43(1):1-7 PMID: 13570988
  106. Mechanism of suckling-rat hypercholesteremia. II. Cholesterol biosynthesis and cholic acid turnover studies.
    Lipids. 1967 Mar;2(2):137-42 PMID: 17805740
  107. Clearing-factor lipase in adipose tissue. Studies with puromycin and actinomycin.
    Biochem J. 1968 Feb;106(3):667-76 PMID: 4295776
Article Info
Journal
Die Naturwissenschaften
Abbr.
Naturwissenschaften
ISSN
0028-1042
DOI
10.1007/BF00593615
Published
1969-08-00
Pages
398-405
Language
ger
Region
Germany
NLM ID
0400767
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00593615 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2