CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.

Science (New York, N.Y.) ·Vol. 146 ·No. 3650 ·1964-12-11 ·Pages 1474-6

ENNIS HL, LUBIN M

Abstract

Cycloheximide and acetoxy-cycloheximide specifically inhibit protein synthesis in L-cells growing in suspension culture. In extracts of rat liver, the drugs inhibit transfer of amino acid from soluble RNA to polypeptide. Unlike puromycin, these drugs do not accelerate release of nascent polypeptide chains. The drugs have no effect on protein synthesis in extracts of Escherichia coli.

Keywords

AMINO ACID METABOLISM ANTIBIOTICS ANTIMETABOLITES EXPERIMENTAL LAB STUDY L CELLS LIVER EXTRACTS PHARMACOLOGY PROTEIN METABOLISM RNA SOLUBLE

MeSH Terms

Amino Acids/metabolism Anti-Bacterial Agents Antimetabolites Cycloheximide Escherichia coli L Cells Liver Extracts Peptides Pharmacology Proteins/metabolism Puromycin RNA Research

Chemicals

Amino Acids Anti-Bacterial Agents Antimetabolites Liver Extracts Peptides Proteins Puromycin RNA Cycloheximide

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

ENNIS H L

LUBIN M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.146.3650.1474

Published

1964-12-11

Pages

1474-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.146.3650.1474 View journal details

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CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.

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