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PMID: 4853617 Published · ppublish English Journal Article

Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.

British journal of pharmacology ·Vol. 50 ·No. 3 ·1974-03-00 ·Pages 405-8

Harris M, Jenkins MV, Wills MR

Abstract

1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.

MeSH Terms
Animals Bone Resorption/drug effects Calcium/metabolism Calcium Radioisotopes Culture Media Culture Techniques Hypocalcemia/metabolism Mice Parathyroid Hormone/antagonists & inhibitors Phenobarbital/pharmacology Phenytoin/administration & dosage,pharmacology Proteins/metabolism
Chemicals
Calcium Radioisotopes Culture Media Parathyroid Hormone Proteins Phenytoin Calcium Phenobarbital
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Harris M
Jenkins M V
Wills M R
References (22)
22 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1974.tb09616.x
Published
1974-03-00
Pages
405-8
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1776707
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1974.tb09616.x PMC Full Text View journal details
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