Latent osteomalacia in epileptic patients on anticonvulsants.

British medical journal ·Vol. 3 ·No. 5829 ·1972-09-23 ·Pages 738-9

Christiansen C, Kristensen M, Rodbro P

Abstract

The bone mineral content was measured in 10 epileptic patients on long-term treatment with phenytoin before and during treatment with vitamin D. None of the patients showed biochemical signs of osteomalacia. Initially subnormal values for bone mineral content were found, which increased significantly during treatment. The results suggest the occurrence of latent osteomalacia in a fairly high proportion of epileptic patients on anticonvulsants.

MeSH Terms

Adult Bone and Bones/analysis Calcium/therapeutic use Epilepsy/drug therapy Female Humans Male Middle Aged Minerals/analysis Osteomalacia/chemically induced Phenytoin/adverse effects,therapeutic use Vitamin D/therapeutic use

Chemicals

Minerals Vitamin D Phenytoin Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Christiansen C

Kristensen M

Rodbro P

References (6)

6 references, click to expand

Precision and accuracy of bone mineral determination by direct photon absorptiometry.
Invest Radiol. 1968 May-Jun;3(3):141-50 PMID: 5659192
25-hydroxycholecalciferol. The probable metabolically active form of vitamin D3: its identification and subcellular site of action.
Arch Intern Med. 1969 Oct;124(4):442-50 PMID: 4309854
Altered calcium metabolism in epileptic children on anticonvulsants.
Br Med J. 1971 Oct 23;4(5781):202-4 PMID: 5115570
Rapid determination of serum diphenylhydantoin by gas chromatography.
Med Lab Technol. 1971 Oct;28(4):377-81 PMID: 5116324
Bone density in patients receiving long-term anticonvulsant therapy.
Acta Neurol Scand. 1971;47(5):650-1 PMID: 5139727
The mineral content in bone. Measured by means of 27.5 keV radiation from 125I.
Acta Radiol Suppl. 1972;313:214-20 PMID: 4374020

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5829.738

Published

1972-09-23

Pages

738-9

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1788670

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5829.738 PMC Full Text

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