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PMID: 4842127 Published · ppublish English Journal Article

Diminished virulence of glucan synthesis-defective mutants of Streptococcus mutans.

Infection and immunity ·Vol. 10 ·No. 1 ·1974-07-00 ·Pages 197-203

Tanzer JM, Freedman ML, Fitzgerald RJ, Larson RH

Abstract

The virulence of cell surface-associated, glucan synthesis-defective mutants of Streptococcus mutans strain 6715-13 was studied. Representatives from three groups of such mutants were tested for their pathogenicity in conventionalized, specific pathogen-free rats and gnotobiotic rats. The mutants differ from the wild-type strain in that each failed to form plaque on the smooth surfaces of the teeth and to cause smooth surface caries. Although the ability to form cell surface-associated glucans was not a strict requirement for the expression of virulence in the sulci of the teeth, it augmented virulence at such sites. However, the ability to form cell surface-associated glucans and to adhere to the teeth was clearly not the sole determinant of virulence.

MeSH Terms
Animals Dental Caries/microbiology Dental Plaque/microbiology Diet, Cariogenic Drug Resistance, Microbial Feces/microbiology Germ-Free Life Glycogen/biosynthesis Molar/microbiology Mutation Rats Streptococcus/isolation & purification,pathogenicity Streptomycin Virulence
Chemicals
Glycogen Streptomycin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tanzer J M
Freedman M L
Fitzgerald R J
Larson R H
References (50)
50 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.10.1.197-203.1974
Published
1974-07-00
Pages
197-203
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414977
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.10.1.197-203.1974 PMC Full Text View journal details
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