Clearance concepts in pharmacokinetics.

Journal of pharmacokinetics and biopharmaceutics ·Vol. 1 ·No. 2 ·1973-04-00 ·Pages 123-36

Rowland M, Benet LZ, Graham GG

Abstract

暂无摘要

MeSH Terms

Absorption Biopharmaceutics Dose-Response Relationship, Drug Glomerular Filtration Rate Half-Life Kidney/metabolism Kinetics Liver/metabolism Mathematics Models, Biological Perfusion Pharmaceutical Preparations/metabolism Regional Blood Flow Time Factors

Chemicals

Pharmaceutical Preparations

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rowland M

Benet L Z

Graham G G

References (11)

11 references, click to expand

Generalized solution to linear, to-compartment, open model for drug distribution.
J Theor Biol. 1970 Oct;29(1):63-8 PMID: 5493292
Pharmacokinetic basis for the influence of route of administration on the area under the plasma concentration-time curve.
J Pharm Sci. 1969 Dec;58(12):1477-80 PMID: 5353263
Thiopental pharmacokinetics.
J Pharm Sci. 1968 Aug;57(8):1346-51 PMID: 5677337
Influence of route of administration on drug availability.
J Pharm Sci. 1972 Jan;61(1):70-4 PMID: 5019220
Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo.
Eur J Pharmacol. 1972 Mar;17(3):352-6 PMID: 5022150
In vitro-in vivo correlation of drug metabolism--deamination of 1- -D-arabinofuranosylcytosine.
Biochem Pharmacol. 1972 Jan;21(1):1-16 PMID: 4500983
Preliminary model for methotrexate pharmacokinetics.
J Pharm Sci. 1970 Feb;59(2):149-54 PMID: 5411336
Application of clearance and volume of distribution to the plateau principle of drugs.
J Pharm Sci. 1970 Oct;59(10):1423-7 PMID: 5471947
THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN.
J Clin Invest. 1945 May;24(3):388-404 PMID: 16695228
Effect of perfusion rate and distribution factors on drug elimination kinetics in a perfused organ system.
J Pharm Sci. 1968 Nov;57(11):1991-3 PMID: 4177837
A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats.
Eur J Pharmacol. 1970 Jan;9(1):99-105 PMID: 5434299

Article Info

Journal

Journal of pharmacokinetics and biopharmaceutics

Abbr.

J Pharmacokinet Biopharm

ISSN

0090-466X

DOI

10.1007/BF01059626

Published

1973-04-00

Pages

123-36

Language

English

Region

United States

NLM ID

0357115

Subset

External Links

PubMed source DOI: 10.1007/BF01059626

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Clearance concepts in pharmacokinetics.

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