Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo.

Analgesics/metabolism Animals Antidepressive Agents/metabolism Antipyrine/blood,metabolism Desipramine/blood,metabolism Half-Life In Vitro Techniques Ketones/blood,metabolism Kinetics Liver/metabolism Models, Biological Nortriptyline/blood,metabolism Perfusion Phenylbutazone/blood,metabolism Rats Tremorine/blood,metabolism

Analgesics Antidepressive Agents Ketones Nortriptyline Phenylbutazone Antipyrine Desipramine Tremorine