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PMID: 468908 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cytochalasin B inhibition of endothelial proliferation at wound edges in vitro.

The Journal of cell biology ·Vol. 81 ·No. 2 ·1979-05-00 ·Pages 348-54

Selden SC, Schwartz SM

Abstract

Cytochalasin B prevents both migration and wound-associated replication when applied to wounded monolayers of bovine endothelium in tissue culture. The normal low background rate of replication in undisturbed areas of the cultures is not inhibited by cytochalasin B. These results suggest that some form of movement may be required for initiation of wound-associated replication by endothelial cells.

MeSH Terms
Animals Aorta Cattle Cell Line Cell Movement/drug effects Cytochalasin B/pharmacology DNA/biosynthesis Dose-Response Relationship, Drug Endothelium/drug effects,physiology Mitosis/drug effects Wound Healing/drug effects
Chemicals
Cytochalasin B DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Selden S C
Schwartz S M
References (20)
20 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.81.2.348
Published
1979-05-00
Pages
348-54
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2110320
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.81.2.348 PMC Full Text View journal details
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