Selection for high mutation rates in chemostats.

Genetics ·Vol. 77 ·No. 2 ·1974-06-00 ·Pages 169-84

Cox EC, Gibson TC

Abstract

Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.

MeSH Terms

Bacteriological Techniques Carbon Radioisotopes Culture Media Escherichia coli Genes Genetics, Microbial Genotype Mutation Probability Selection, Genetic

Chemicals

Carbon Radioisotopes Culture Media

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cox E C

Gibson T C

References (10)

10 references, click to expand

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Genetic analysis of sul mutants of Escherichia coli B.
Genet Res. 1971 Jun;17(3):185-93 PMID: 4946930
The genetics of a mutator gene in Drosophila melanogaster.
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Fitness of an Escherichia coli mutator gene.
Science. 1970 Aug 14;169(3946):686-8 PMID: 4914168
In vitro characterization of a mutator T4 DNA polymerase.
Genetics. 1973 Apr;73:Suppl 73:131-6 PMID: 4711554
Population changes in continuously growing mutator cultures of Escherichia coli.
Genetics. 1973 Apr;73:Suppl 73:41-4 PMID: 4576119
Segregation of the Selective Advantage Obtained through Orthoselection in Escherichia Coli.
Genetics. 1955 Nov;40(6):937-50 PMID: 17247601
A proposal for a uniform nomenclature in bacterial genetics.
Genetics. 1966 Jul;54(1):61-76 PMID: 5961488
Mutator gene studies in Escherichia coli: the mutS gene.
Genetics. 1972 Dec;72(4):551-67 PMID: 4569178
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Proc Natl Acad Sci U S A. 1967 Nov;58(5):1895-902 PMID: 4866980

Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/77.2.169

Published

1974-06-00

Pages

169-84

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1213122

Subset

External Links

PubMed source DOI: 10.1093/genetics/77.2.169 PMC Full Text View journal details

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Selection for high mutation rates in chemostats.

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