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PMID: 4596514 Published · ppublish English Journal Article

Cellular requirements for the primary in vitro antibody response to DNP-ficoll.

The Journal of experimental medicine ·Vol. 139 ·No. 5 ·1974-05-01 ·Pages 1354-60

Mosier DE, Johnson BM, Paul WE, McMaster PR

Abstract

The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.

MeSH Terms
Animals Antibodies/analysis Antibody Formation Antibody-Producing Cells/immunology Antigens B-Lymphocytes/immunology Cells, Cultured Dinitrophenols Erythrocytes/immunology Hemolytic Plaque Technique Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Mice Mice, Inbred BALB C Mice, Inbred Strains Polysaccharides Propylene Glycols Sheep/immunology Spleen/cytology,immunology Sucrose T-Lymphocytes/immunology
Chemicals
Antibodies Antigens Dinitrophenols Immunoglobulin G Immunoglobulin M Polysaccharides Propylene Glycols Sucrose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mosier D E
Johnson B M
Paul W E
McMaster P R
References (15)
15 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.139.5.1354
Published
1974-05-01
Pages
1354-60
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139667
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.139.5.1354 PMC Full Text View journal details
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