Class, subclass, and allelic exclusion of membrane-bound Ig of human B lymphocytes.

The Journal of experimental medicine ·Vol. 136 ·No. 2 ·1972-08-01 ·Pages 409-14

Fröland SS, Natvig JB

Abstract

Membrane-bound immunoglobulins of peripheral blood B lymphocytes and of lymphocytes from an IgG chronic lymphocytic leukemia showed restriction to one immunoglobulin class, one IgG subclass, and one Gm allotype. Certain antigens in the C-terminal part of IgG Fc were not exposed on the cell surface.

MeSH Terms

Alleles Cell Membrane/immunology Fluorescent Antibody Technique Humans Immunity, Cellular Immunogenetics Immunoglobulin G/classification Immunoglobulins/classification In Vitro Techniques Isoantigens Leukemia, Lymphoid/immunology Lymphocytes/immunology

Chemicals

Immunoglobulin G Immunoglobulins Isoantigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fröland S S

Natvig J B

References (14)

14 references, click to expand

Chromatographic purification of tetramethylrhodamine-immune globulin conjugates and their use in the cellular localization of rabbit gamma-globulin polypeptide chains.
J Immunol. 1965 Aug;95(2):230-45 PMID: 4158328
Production of different classes of immunoglobulins by individual cells in the guinea-pig.
Immunology. 1969 Mar;16(3):349-59 PMID: 4181539
Studies on rabbit lymphocytes in vitro. XI. Superaddition of anti-allotypic lymphocyte transformation: evidence for multipotent lymphoid cells.
J Immunol. 1970 Jan;104(1):103-13 PMID: 5411500
Immunoglobulin spots on the surface of rabbit lymphocytes.
J Exp Med. 1970 Nov;132(5):1001-18 PMID: 4919141
Membrane-associated immunoglobulin of rabbit peripheral blood lymphocytes: allelic exclusion at the b locus.
Proc Natl Acad Sci U S A. 1971 Feb;68(2):430-4 PMID: 4100380
Demonstration of heavy and light chain antigenic determinants on the cell-bound receptor for antigen. Similarities between membrane-attached and humoral antibodies produced by the same cell.
J Exp Med. 1970 Dec 1;132(6):1233-49 PMID: 4101973
Localization of Gm markers to different molecular regions of the Fc fragment.
Clin Exp Immunol. 1971 May;8(5):685-700 PMID: 4103295
Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.
J Clin Invest. 1971 Nov;50(11):2368-75 PMID: 4999540
Cell surface associated gamma globulins in lymphocytes. II. The pluripotentiality of mouse spleen lymphocytes.
J Immunol. 1971 Dec;107(6):1583-92 PMID: 4107653
Immunoglobulin (Ig) receptors on human peripheral leukocytes. II. Class restriction Ig receptors.
J Immunol. 1971 Dec;107(6):1637-42 PMID: 4107656
Surface-bound immunoglobulin as a marker of B lymphocytes in man.
Nat New Biol. 1971 Dec 22;234(51):251-2 PMID: 4942988
Detection of genetic markers of human immunoglobulins by immunofluorescence technique.
Ann N Y Acad Sci. 1971 Jun 21;177:326-34 PMID: 4110294
The diversity and specialization of immunocytes.
Prog Allergy. 1970;14:145-207 PMID: 4949435
Lymphocytes in human immunodeficiency states: a study of membrane-associated immunoglobulins.
Eur J Immunol. 1971 Dec;1(6):482-6 PMID: 18236610

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.136.2.409

Published

1972-08-01

Pages

409-14

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139201

Subset

External Links

PubMed source DOI: 10.1084/jem.136.2.409 PMC Full Text View journal details

Analysis Services

Class, subclass, and allelic exclusion of membrane-bound Ig of human B lymphocytes.

Contact

WeChat Official Account