Home LiteratureArticle Details
PMID: 4100380 Published · ppublish English Journal Article

Membrane-associated immunoglobulin of rabbit peripheral blood lymphocytes: allelic exclusion at the b locus.

Davie JM, Paul WE, Mage RG, Goldman MB

Abstract

Light chain allotypic determinants were demonstrated on the surface of peripheral blood lymphocytes of rabbits. By means of a combined immunofluorescent and autoradiographic technique, a great majority of the individual lymphocytes of rabbits heteroxygous at the b locus were shown to have detectable quantities of only one allotype. A small proportion of lymphocytes appeared to possess both allelic forms of L chains.

MeSH Terms
Alleles Animals Antibodies/isolation & purification Antigen-Antibody Reactions Antigens/analysis Autoradiography Binding Sites Cell Membrane/immunology Epitopes
Chemicals
Antibodies Antigens Epitopes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Davie J M
Paul W E
Mage R G
Goldman M B
References (16)
16 references, click to expand
  1. Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues.
    J Exp Med. 1965 Nov 1;122(5):853-76 PMID: 4159057
  2. Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2.
    J Exp Med. 1966 Mar 1;123(3):547-58 PMID: 4160817
  3. An effect upon the regulation of gene expression: allotype suppression at the a locus in heterozygous offspring of immunized rabbits.
    J Immunol. 1967 Mar;98(3):502-9 PMID: 4164057
  4. Rabbit light chains lacking b-allotypic specificites. I. Isolation and characterization of light chains from normal and allotype suppressed homozygotes.
    J Immunol. 1969 Mar;102(3):638-46 PMID: 4975225
  5. Production of different classes of immunoglobulins by individual cells in the guinea-pig.
    Immunology. 1969 Mar;16(3):349-59 PMID: 4181539
  6. Transformation of rabbit lymphocytes by anti-allotype serum: ultrastructure of transformed cells and suppression of responding cells by foetal exposure to anti-allotype serum.
    Immunology. 1969 Jun;16(6):791-802 PMID: 4182370
  7. Studies on rabbit lymphocytes in vitro. XI. Superaddition of anti-allotypic lymphocyte transformation: evidence for multipotent lymphoid cells.
    J Immunol. 1970 Jan;104(1):103-13 PMID: 5411500
  8. Immunoglobulin determinants on the surface of mouse lymphoid cells.
    Nature. 1970 Feb 7;225(5232):553-4 PMID: 4189355
  9. Immunoglobulin determinants on the lymphocytes of normal rabbits. I. Demonstration by the mixed antiglobulin reaction of determinants recognized by anti-gamma, anti-mu, anti-Fab and anti-allotype sera, anti-As4 and anti-As6.
    Immunology. 1970 Mar;18(3):417-29 PMID: 4192262
  10. Absence of gamma-globulin receptors on mouse plasmacytoma cells.
    Nature. 1970 Jul 25;227(5256):395-7 PMID: 4193642
  11. Immunoglobulin allotypic determinants on rabbit lymphocytes.
    Nature. 1970 Sep 5;227(5262):1051-3 PMID: 4194773
  12. Immunoglobulin spots on the surface of rabbit lymphocytes.
    J Exp Med. 1970 Nov;132(5):1001-18 PMID: 4919141
  13. A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY.
    Virology. 1963 Aug;20:642-4 PMID: 14059832
  14. IMMUNOCHEMICAL IDENTIFICATION AND GENETICS OF RABBIT GAMMA-GLOBULIN ALLOTYPES.
    J Immunol. 1963 Sep;91:403-15 PMID: 14071032
  15. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
    Biochem J. 1963 Oct;89:114-23 PMID: 14097352
  16. STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.
    J Exp Med. 1965 Aug 1;122:423-40 PMID: 14316952
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1971-02-00
Pages
430-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388954
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com