Home LiteratureArticle Details
PMID: 4552552 Published · ppublish English Journal Article

Nonproductive infection and induction of cellular deoxyribonucleic acid synthesis by bovine adenovirus type 3 in a contact-inhibited mouse cell line.

Journal of virology ·Vol. 9 ·No. 3 ·1972-03-00 ·Pages 465-73

Tsukamoto K, Sugino Y

Abstract

Bovine adenovirus type 3 (BAV-3), which has been reported to produce tumors in newborn hamsters, induced cellular deoxyribonucleic acid (DNA) synthesis in a contact-inhibited mouse kidney cell line (C3H2K). In this system, the virus did not multiply, whereas virus-specific tumor antigen (T antigen) was detected in nearly all cells. Replication of viral DNA could not be detected by DNA-DNA hybridization on membrane filters. The cellular DNA synthesis induced by BAV-3 did occur in the absence of added serum. Extent of induction of cellular DNA synthesis was closely correlated with the multiplicity of infection. Cells activated to synthesize DNA in the serum-free medium by the virus infection progressed to cell division without noticeable cell killing.

MeSH Terms
Adenoviridae/growth & development,immunology,metabolism Animals Antigens, Viral/isolation & purification Autoradiography Cattle Cell Division Cell Line/growth & development,immunology,metabolism Contact Inhibition DNA/biosynthesis DNA Replication DNA, Viral/biosynthesis Fluorescent Antibody Technique Kidney Mice Microscopy, Fluorescence Nucleic Acid Hybridization Phosphates/metabolism Phosphorus Isotopes Thymidine/metabolism Tritium Virus Replication
Chemicals
Antigens, Viral DNA, Viral Phosphates Phosphorus Isotopes Tritium DNA Thymidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tsukamoto K
Sugino Y
References (30)
30 references, click to expand
  1. Induction of cellular deoxyribonuleic acid synthesis by simian virus 40.
    J Virol. 1967 Aug;1(4):738-46 PMID: 4316230
  2. The initiation of cell division in a contact-inhibited mammalian cell line.
    J Cell Physiol. 1965 Dec;66(3):325-33 PMID: 5884360
  3. The response of BHK21 cells to infection with type 12 adenovirus. 1. Cell killing and T antigen synthesis as correlated viral genome functions.
    Virology. 1969 Dec;39(4):642-52 PMID: 4902254
  4. "Contact inhibition" of cell division in 3T3 cells.
    Proc Natl Acad Sci U S A. 1968 May;60(1):300-4 PMID: 5241531
  5. A quantitative assay for DNA-DNA hybrids using membrane filters.
    Biochem Biophys Res Commun. 1966 Aug 23;24(4):554-8 PMID: 5338489
  6. The induction of amitotic nuclear division by pseudorabies virus multiplying in single rabbit kidney cells.
    Virology. 1960 May;11:1-11 PMID: 14437457
  7. [STUDY ON VIRUS-CHROMOSOME RELATIONSHIPS. I. SIMPLIFIED TECHNIC FOR CHROMOSOME PREPARATION].
    Ann Inst Pasteur (Paris). 1964 Apr;106:561-74 PMID: 14145241
  8. Behavior of tissue culture cells infected with polyoma virus.
    Proc Natl Acad Sci U S A. 1970 Nov;67(3):1214-20 PMID: 4320974
  9. DNA synthesis in rat embryo cells infected with polyoma virus.
    Virology. 1966 May;29(1):167-70 PMID: 4287024
  10. EFFECT OF POLYOMA VIRUS ON THE REPLICATIVE MECHANISM OF MOUSE EMBRYO CELLS.
    Virology. 1965 May;26:73-84 PMID: 14293315
  11. Release from density dependent growth inhibition by proteolytic enzymes.
    Nature. 1970 Aug 22;227(5260):843-5 PMID: 5464581
  12. Bovine adenovirus type 3: detection of specific tumor and T antigens.
    Virology. 1967 Apr;31(4):727-9 PMID: 6022697
  13. Induction of cell division in medium lacking serum growth factor by SV40.
    Virology. 1971 May;44(2):359-70 PMID: 4105257
  14. Acquisition of enzyme function by mouse kidney cells abortively infected with papovavirus SV40.
    Proc Natl Acad Sci U S A. 1966 Aug;56(2):463-70 PMID: 4291009
  15. Biochemistry of vaccinia-infected mouse fibroblasts (strain L-M). I. Effects on nucleic acid and protein synthesis.
    Virology. 1962 Oct;18:274-85 PMID: 14033129
  16. Simplified method of dispersion of monkey kidney cells with trypsin.
    Virology. 1956 Aug;2(4):575-6 PMID: 13352782
  17. Unstable DNA synthesized by polyoma virus-infected cells.
    Virology. 1966 Sep;30(1):74-81 PMID: 4287878
  18. Stimulation of DNA synthesis in mouse cell line 3T3 by Simian virus 40.
    Proc Natl Acad Sci U S A. 1966 Oct;56(4):1170-6 PMID: 4291201
  19. Virus infection of cells in mitosis. I. Observations on the recruitment of cells in karyokinesis into giant cells induced by herpes simplex virus and bearing on the site of virus antigen formation.
    Virology. 1961 Apr;13:387-401 PMID: 13742872
  20. BIOCHEMICAL STUDIES ON ADENOVIRUS MULTIPLICATION, VI. PROPERTIES OF HIGHLY PURIFIED TUMORIGENIC HUMAN ADENOVIRUSES AND THEIR DNA.
    Proc Natl Acad Sci U S A. 1964 Jun;51:1251-9 PMID: 14215651
  21. Synchronized cell division induced by medium change.
    Exp Cell Res. 1967 Oct;48(1):226-8 PMID: 4168505
  22. Topoinhibition and serum requirement of transformed and untransformed cells.
    Nature. 1970 Aug 22;227(5260):802-6 PMID: 4317354
  23. Oncogenicity of bovine adenovirus type 3 in hamsters.
    Nature. 1966 Jul 2;211(5044):102 PMID: 4290895
  24. Induction of T antigen, new surface antigen, and transplantation immunity by a nontumorigenic variant of type 3 bovine adenovirus.
    Cancer Res. 1970 Jun;30(6):1795-8 PMID: 4196073
  25. Stimulation of DNA synthesis in cultures of mouse embryo fibroblast-like cells.
    J Cell Physiol. 1970 Jun;75(3):305-13 PMID: 5449697
  26. Temperature sensitivity of polyoma virus, induction of cellular DNA synthesis, and multiplication of transformed cells at high temperature.
    Proc Natl Acad Sci U S A. 1967 Nov;58(5):1938-43 PMID: 4295583
  27. The induction of cellular DNA synthesis by simian virus 40 in contact-inhibited and in x-irradiated cells.
    Proc Natl Acad Sci U S A. 1966 Sep;56(3):918-25 PMID: 16578647
  28. INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS.
    Proc Natl Acad Sci U S A. 1965 Feb;53:403-10 PMID: 14294074
  29. Induction of DNA synthesis by adenoviruses in contact-inhibited hamster cells.
    Virology. 1968 Nov;36(3):422-33 PMID: 5722184
  30. On the mechanism of polyoma virus-induced synthesis of cellular DNA.
    Proc Natl Acad Sci U S A. 1965 Dec;54(6):1584-92 PMID: 4286562
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.9.3.465-473.1972
Published
1972-03-00
Pages
465-73
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356320
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.9.3.465-473.1972 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2