Behavior of tissue culture cells infected with polyoma virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 3 ·1970-11-00 ·Pages 1214-20

Dulbecco R

Abstract

Infection of tissue culture cells with the oncogenic polyoma virus, or its temperature-sensitive mutant Ts-a, causes several changes other than the previously known induction of cellular DNA synthesis. Cellular movement, survival, and mitotic rate are enhanced in low-serum medium, and morphology is changed; the cellular growth parameters, wound serum requirement, and topoinhibition are markedly decreased. The changes are similar to those that occur in cell transformation and are produced by viral functions known to be expressed in transformed cells. Clues as to the possible mechanisms of all these changes are analyzed and a possible mechanism is discussed.

MeSH Terms

Cell Movement Cell Transformation, Neoplastic Culture Techniques Mitosis Polyomavirus

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Dulbecco R

References (17)

17 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.3.1214

Published

1970-11-00

Pages

1214-20

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283339

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.3.1214 PMC Full Text View journal details

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Behavior of tissue culture cells infected with polyoma virus.

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