Structure and properties of a synthetic analogue of bacterial iron--sulfur proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 9 ·1972-09-00 ·Pages 2437-41

Herskovitz T, Averill BA, Holm RH, Ibers JA, Phillips WD, Weiher JF

Abstract

The compound (Et(4)N)(2)[Fe(4)S(4)(SCH(2)Ph)(4)] has been prepared and its structure determined by x-ray diffraction. The Fe(4)S(4) core of the anion possesses a configuration of D(2d) symmetry that is closely related to the Fe(4)S(4) active-site structures of the high-potential iron protein from Chromatium and the ferredoxin from Micrococcus aerogenes. Electronic properties of the tetrameric anion have been partially characterized by measurement of proton magnetic resonance, Mössbauer, photoelectron, and electronic spectra, and magnetic susceptibility. Comparison of corresponding properties of [Fe(4)S(4)(SCH(2)Ph)(4)](2-) and the proteins implies that the oxidation levels of the synthetic tetramer, the reduced form of the high-potential protein, and the oxidized form of the 8-Fe ferredoxins are equivalent. The tetramer possesses the one-electron redox capacity associated with the 4-Fe centers of the ferredoxins. The structural and collective electronic features of [Fe(4)S(4)(SCH(2)Ph)(4)](2-) reveal it to be the first well-defined synthetic analogue of the active site of an iron-sulfur protein.

MeSH Terms

Bacterial Proteins Chemical Phenomena Chemistry, Physical Ferredoxins Iron Iron Isotopes Magnetic Resonance Spectroscopy Magnetics Models, Chemical Organometallic Compounds Oxidation-Reduction Potentiometry Spectrum Analysis Sulfides Temperature X-Ray Diffraction

Chemicals

Bacterial Proteins Ferredoxins Iron Isotopes Organometallic Compounds Sulfides Iron

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Herskovitz T

Averill B A

Holm R H

Ibers J A

Phillips W D

Weiher J F

References (19)

19 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.9.2437

Published

1972-09-00

Pages

2437-41

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426959

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.9.2437 PMC Full Text View journal details

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Structure and properties of a synthetic analogue of bacterial iron--sulfur proteins.

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