Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 .

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 2 ·1972-02-00 ·Pages 348-52

Shows TB

Abstract

By use of human-mouse somatic cell hybrids, an autosomal gene linkage has been determined for the human loci controlling the phenotypes of lactate dehydrogenase-A (EC 1.1.1.27) and esterase-A(4) (EC 3.1.1.2). These structural loci were not linked to the lactate dehydrogenase-B, peptidase-B linkage, the X chromosome, the E(17) chromosome, or to nine other enzyme phenotypes examined.

MeSH Terms

Animals Cell Line Clone Cells/enzymology Connective Tissue Esterases/isolation & purification Fibroblasts/enzymology Genetic Linkage Humans Hybrid Cells/enzymology Hybridization, Genetic L-Lactate Dehydrogenase/isolation & purification Lung Mice Phenotype Thymidine Kinase

Chemicals

L-Lactate Dehydrogenase Thymidine Kinase Esterases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Shows T B

References (31)

31 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.69.2.348

Published

1972-02-00

Pages

348-52

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC426455

Subset

External Links

PubMed source DOI: 10.1073/pnas.69.2.348 PMC Full Text View journal details

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Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 .

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