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PMID: 4393372 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article

Comparative trial of serotonin antagonists in the management of migraine.

British medical journal ·Vol. 2 ·No. 5705 ·1970-05-09 ·Pages 327-30

Lance JW, Anthony M, Somerville B

Abstract

The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with BC105 were significantly better than those with placebo (P<0.02). The total improvement rates with methdilazine (45%) and cyproheptadine (43%) were better than those with placebo (32%) but did not achieve statistical significance. A new preparation, methylergol carbamide maleate, which is chemically related to methysergide, did not give better results than placebo.

MeSH Terms

Clinical Trials as Topic Cyproheptadine/therapeutic use Ergolines/adverse effects,therapeutic use Female Histamine H1 Antagonists/therapeutic use Humans Male Methysergide/adverse effects,therapeutic use Migraine Disorders/drug therapy Muscle Cramp/chemically induced Nausea/chemically induced Phenothiazines/therapeutic use Placebos Pyrrolidines/therapeutic use Serotonin Antagonists Thiophenes/therapeutic use

Chemicals

Ergolines Histamine H1 Antagonists Phenothiazines Placebos Pyrrolidines Serotonin Antagonists Thiophenes Cyproheptadine Methysergide

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lance J W

Anthony M

Somerville B

References (13)

13 references, click to expand

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An antaminic drug, BC 105, in the prophylaxis of migraine. Pharmacological, clinical, and therapeutic experiences.
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Clinical trial of a new serotonin antagonist, BC105, in the prevention of migraine.
Med J Aust. 1968 Jan 13;1(2):54-5 PMID: 4867512
Indomethacin in migraine.
Med J Aust. 1968 Jan 13;1(2):56-7 PMID: 4867513
Double-blind crossover comparison of bc-105, methysergide and placebo in the prophylaxis of migraine headache.
Headache. 1968 Oct;8(3):118-26 PMID: 4892617
Studies on headache. The mode of action of UML-491 and its relevance to the nature of vascular headache of the migraine type.
Arch Neurol. 1961 Mar;4:235-40 PMID: 13719415
A serotonin antagonist in the treatment of allergic and allied disorders.
Ann Allergy. 1961 Feb;19:164-71 PMID: 13770797
CLINICAL TRIAL OF METHYSERGIDE AND OTHER PREPARATIONS IN THE MANAGEMENT OF MIGRAINE.
J Neurol Neurosurg Psychiatry. 1964 Oct;27:463-9 PMID: 14213477
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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5705.327

Published

1970-05-09

Pages

327-30

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1700164

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5705.327 PMC Full Text

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Comparative trial of serotonin antagonists in the management of migraine.

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