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PMID: 5297527 Published · ppublish English Journal Article

The effect of 5-hydroxytryptamine on the cotton pellet local inflammatory response in the rat.

The Journal of experimental medicine ·Vol. 125 ·No. 3 ·1967-03-01 ·Pages 501-10

Bianchine JR, Eade NR

Abstract

The cotton pellet technique was used to evaluate the effect of 5-HT and certain related compounds on granuloma formation in the rat. 5-HT (10 mg/kg) significantly decreased granuloma formation, significantly increased adrenal weight, and significantly decreased thymus weight in normal rats, and significantly decreased granuloma formation and thymus weight in sham-operated rats. On the other hand, 5-HT (10 mg/kg) significantly increased granuloma weight in adrenalectomized rats. Methysergide (1 mg/kg) blocked the inhibitory effect of 5-HT on granuloma formation as well as the changes in weight of adrenal and thymus glands. 5-HIAA (11 mg/kg) and 5-HTP (13 mg/kg) failed to alter granuloma formation.

MeSH Terms
5-Hydroxytryptophan/pharmacology Adrenal Glands/drug effects,physiology Granuloma Hydroxyindoleacetic Acid/pharmacology Inflammation Methysergide/pharmacology Organ Size Serotonin/pharmacology Thymus Gland/drug effects
Chemicals
Serotonin Hydroxyindoleacetic Acid 5-Hydroxytryptophan Methysergide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bianchine J R
Eade N R
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.125.3.501
Published
1967-03-01
Pages
501-10
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138287
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.125.3.501 PMC Full Text View journal details
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