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PMID: 4385111 Published · ppublish English Journal Article

Liberation of alpha-methyldopamine as a "false" sympathetic transmitter after pretreatment of cats with alpha-methyldopa and disulfiram.

Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie ·Vol. 258 ·No. 2 ·1967-00-00 ·Pages 181-96

Thoenen H, Haefely W, Gey KF, Hürlmann A

Abstract

暂无摘要

MeSH Terms
Animals Blood Pressure/drug effects Catecholamines/analysis,metabolism Cats Chromatography, Paper Disulfiram/pharmacology Dopamine/analysis Epinephrine/analysis Heart/physiology In Vitro Techniques Methyldopa/pharmacology Mixed Function Oxygenases/antagonists & inhibitors Myocardium/analysis Neurotransmitter Agents/metabolism Nictitating Membrane/physiology Norepinephrine/analysis,metabolism,pharmacology Normetanephrine/analysis Perfusion Spleen/analysis,innervation,physiology Sympathetic Nervous System/drug effects,physiology Synaptic Transmission
Chemicals
Catecholamines Neurotransmitter Agents Normetanephrine Methyldopa Mixed Function Oxygenases Disulfiram Dopamine Norepinephrine Epinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Thoenen H
Haefely W
Gey K F
Hürlmann A
References (32)
32 references, click to expand
  1. BETA-HYDROXYLATED SYMPATHOMIMETIC AMINES AS FALSE NEUROTRANSMITTERS.
    Br J Pharmacol Chemother. 1965 Apr;24:477-84 PMID: 14320862
  2. Subcellular distribution and release by sympathetic nerve stimulation of dopamine and alpha-methyl dopamine.
    J Pharmacol Exp Ther. 1966 Apr;152(1):51-5 PMID: 5937401
  3. A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.
    J Pharm Pharmacol. 1963 Apr;15:221-4 PMID: 14025624
  4. [STRUCTURE-ACTIVITY RELATIONS IN A SERIES OF PHENYLETHYLAMINES AFTER FUNCTIONAL ISOLATION OF THEIR EFFECT ON ADRENERGIC RECEPTORS].
    Helv Physiol Pharmacol Acta. 1964 Oct;64:C125-7 PMID: 14246280
  5. Biochemical aspects of release of norepinephrine and other amines from sympathetic nerve endings.
    Pharmacol Rev. 1966 Mar;18(1):513-23 PMID: 5904165
  6. BINDING AND RELEASE OF METARAMINOL: MECHANISM OF NOREPINEPHRINE DEPLETION BY ALPHA-METHYL-M-TYROSINE AND RELATED AGENTS.
    J Pharmacol Exp Ther. 1964 Nov;146:194-9 PMID: 14236930
  7. [The replacement of noradrenaline by dopamine as a postganglionic sympathetic transmitter in the inhibition of dopamine beta-hydroxylase by disulfiram].
    Helv Physiol Pharmacol Acta. 1966 Nov;68:C118-9 PMID: 5987882
  8. THE EFFECT OF SYMPATHETIC NERVE STIMULATION ON VOLUME, VASCULAR RESISTANCE, AND NOREPINEPHRINE OUTPUT IN THE ISOLATED PERFUSED SPLEEN OF THE CAT, AND ITS MODIFICATION BY COCAINE.
    J Pharmacol Exp Ther. 1964 Jan;143:57-63 PMID: 14112308
  9. The effect of stimulation of sympathetic nerves in the cat treated with reserpine, alpha-methyldopa and alpha-methylmetatyrosine.
    Br J Pharmacol Chemother. 1966 Jan;26(1):172-85 PMID: 5920649
  10. ON THE MECHANISM OF NORADRENALINE DEPLETION BY ALPHA-METHYL METATYROSINE AND METARAMINOL.
    Acta Pharmacol Toxicol (Copenh). 1964;21:260-71 PMID: 14209617
  11. Adrenergic transmitter changes and response to sympathetic nerve stimulation after differing pretreatment with alpha-methyldopa.
    Br J Pharmacol Chemother. 1967 Sep;31(1):105-19 PMID: 6055245
  12. In-vivo decarboxylation of alpha-methyl DOPA and alpha-methyl metatyrosine.
    Acta Physiol Scand. 1962 Jan;54:87-94 PMID: 13876658
  13. PROPERTIES OF NOREPINEPHRINE STORAGE PARTICLES OF THE RAT HEART.
    J Pharmacol Exp Ther. 1963 Dec;142:299-305 PMID: 14098325
  14. The release of protein from the stimulated adrenal medulla.
    Biochem J. 1965 Dec;97(3):40C-41C PMID: 5881651
  15. SUBCELLULAR DISTRIBUTION OF SOME SYMPATHOMIMETIC AMINES AND THEIR BETA-HYDROXYLATED DERIVATIVES IN THE RAT HEART.
    J Pharmacol Exp Ther. 1965 Apr;148:22-8 PMID: 14279180
  16. INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM.
    Life Sci (1962). 1964 Jul;3:763-7 PMID: 14203977
  17. THE EFFECT OF SYMPATHETIC NERVE STIMULATION IN CATS PRETREATED WITH A-METHYL-META-TYROSINE.
    Life Sci (1962). 1965 Apr;4:913-8 PMID: 14322156
  18. A fluorimetric method for the determination of dopamine (3-hydroxytyramine).
    Acta Physiol Scand. 1958 Dec 15;44(3-4):293-8 PMID: 13617024
  19. [On the effects of alpha-methyl-dopa on the pyrocatecholamine content in guinea pig organs].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Jun 1;251(1):48-61 PMID: 4222456
  20. RELEASE BY SYMPATHETIC STIMULATION OF ALPHA-METHYLNORADRENALINE STORED IN THE HEART AFTER ADMINISTRATION OF ALPHA-METHYLDOPA.
    Experientia. 1963 Dec 15;19:658-9 PMID: 14099879
  21. Storage particles in noradrenergic tissues.
    Pharmacol Rev. 1966 Mar;18(1):425-32 PMID: 5904157
  22. A method for the fluorimetric determination of adrenaline and noradrenaline in tissues.
    Acta Physiol Scand. 1958 Dec 15;44(3-4):273-92 PMID: 13617023
  23. [Noradrenalin loss from the isolated rabbit heart following sympathetic nerve irritation and its pharmacological alteration].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1962;244:81-96 PMID: 13955624
  24. Liberation of p-hydroxynorephedrine from cat spleen by sympathetic nerve stimulation after pretreatment with amphetamine.
    Life Sci. 1966 Sep;5(18):1715-22 PMID: 5971073
  25. EFFECT OF ALPHA-METHYL-DOPA ON MYOCARDIAL CATECHOLAMINES.
    Experientia. 1963 Nov 15;19:573-5 PMID: 14101511
  26. [Functional importance of liberation of dihydroxyephedrine and dihydroxypseudoephedrine as "false" sympathetic transmitter substances in the heart].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;256(1):1-25 PMID: 4385230
  27. Evidence that the secreting adrenal chromaffin cell releases catecholamines directly from ATP-rich granules.
    J Physiol. 1966 Mar;183(1):236-48 PMID: 5945251
  28. Modification by reserpine of the action of sympathomimetic amines in spinal cats; a classification of sympathomimetic amines.
    J Pharmacol Exp Ther. 1962 Nov;138:170-80 PMID: 13994080
  29. Studies on the enzyme catalyzing the conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.
    J Biol Chem. 1961 Jul;236:2043-9 PMID: 13761407
  30. Inhibition of norepinephrine biosynthesis at the dopamine-beta-hydroxylation stage.
    Pharmacol Rev. 1966 Mar;18(1):77-82 PMID: 5904190
  31. Quantitative aspects of the replacement of norepinephrine by dopamine as a sympathetic transmitter after inhibition of dopamine-beta-hydroxylase by disulfiram.
    J Pharmacol Exp Ther. 1967 May;156(2):246-51 PMID: 6026255
  32. Diminished effects of sympathetic nerve stimulation in cats pretreated with disulfiram; liberation of dopamine as sympathetic transmitter.
    Life Sci. 1965 Nov;4(21):2033-8 PMID: 5866619
Article Info
Journal
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie
Abbr.
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol
DOI
10.1007/BF00535791
Published
1967-00-00
Pages
181-96
Language
English
Region
Germany
NLM ID
0054224
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00535791
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