Trisomy 8p due to the 3:1 segregation of the balanced translocation t(8;15)mat.

Human genetics ·Vol. 46 ·No. 3 ·1979-02-15 ·Pages 335-9

Lazjuk GI, Lurie IW, Usova YI, Gurevich DB, Nedzved MK

Abstract

An additional small G-like chromosome was found in a newborn female with multiple abnormalities and hemorrhagic diathesis. G banding showed that the index patient was trisomic for the short arm of chromosome 8 and revealed the anomaly t(8;15)(q12;p11) in her mother. The relationship between chromosome 8 and multiple hemorrhages is discussed.

MeSH Terms

Abnormalities, Multiple/genetics Chromosome Banding Chromosome Mapping Chromosomes, Human, 13-15 Chromosomes, Human, 6-12 and X Factor VII/genetics Female Genes, Regulator Hemorrhagic Disorders/genetics Humans Infant, Newborn Translocation, Genetic Trisomy

Chemicals

Factor VII

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Lazjuk G I

Lurie I W

Usova Y I

Gurevich D B

Nedzved M K

References (12)

12 references, click to expand

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Duplication-deficiency of the short arm of chromosome 8 following artificial insemination.
Ann Genet. 1976 Dec;19(4):241-7 PMID: 1087853
Partial trisomy 8: further observation of a familial C-G translocation chromosome identified by the Q-staining methods.
J Ment Defic Res. 1973 Mar;17(1):28-32 PMID: 4137098
Trisomy of the short arm of chromosome 8: association with translocation between chromosomes 8 and 22 46,XY,22-,t(8p22q) plus.
Clin Genet. 1973 Jun;4(6):507-16 PMID: 4787842
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00273318

Published

1979-02-15

Pages

335-9

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00273318 View journal details

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Trisomy 8p due to the 3:1 segregation of the balanced translocation t(8;15)mat.

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