Cleavage of mengovirus polyproteins in vivo.
The synthesis of mengovirus-specific proteins in vivo was studied by labeling the viral proteins with radioactive amino acids under conditions in which host protein synthesis was almost completely inhibited. Pulse-chase experiments enabled the kinetic analysis of the cleavages of certain viral protein precursors and the formation of others. The pattern of cleavages of mengovirus precursor polypeptides is similar to that of encephalomyocarditis virus. The major difference between the two viruses seems to be in the molar concentration in which the various primary products are produced. The molar ratio of the A protein, which is the precursor of the capsid proteins, to that of the primary products F and C, is approximately 1.5 to 2.0: 1: 1. Possible explanations for the unequal appearance of the structural and nonstructural proteins are discussed.
20 references, click to expand
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Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.Proc Natl Acad Sci U S A. 1965 Aug;54(2):505-13 PMID: 4285933
-
Evidence for large precursor proteins in poliovirus synthesis.Proc Natl Acad Sci U S A. 1968 Mar;59(3):966-71 PMID: 4296044
-
Polypeptide cleavages in the formation of poliovirus proteins.Proc Natl Acad Sci U S A. 1968 Sep;61(1):77-84 PMID: 4301595
-
Synthesis of ribonucleic acid in cells infected with LSc poliovirus at elevated temperatures.J Virol. 1969 Mar;3(3):297-303 PMID: 4305673
-
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.J Biol Chem. 1969 Aug 25;244(16):4406-12 PMID: 5806584
-
Synthesis and cleavage of enterovirus polypeptides in mammalian cells.J Virol. 1970 Mar;5(3):358-67 PMID: 4314555
-
Further evidence on the formation of poliovirus proteins.J Mol Biol. 1970 May 14;49(3):657-69 PMID: 4318205
-
Effect of temperature on the cleavage of polypeptides during growth of LSc poliovirus.J Mol Biol. 1971 Aug 14;59(3):537-41 PMID: 4328409
-
Determination of the gene sequence of poliovirus with pactamycin.Proc Natl Acad Sci U S A. 1971 Nov;68(11):2852-6 PMID: 4330946
-
Effect of pactamycin on synthesis of poliovirus proteins: a method for genetic mapping.J Virol. 1971 Oct;8(4):395-401 PMID: 4331648
-
Virus-specific proteins synthesized in encephalomyocarditis virus-infected HeLa cells.Proc Natl Acad Sci U S A. 1971 Dec;68(12):3083-7 PMID: 4332006
-
Simple method for the isolation of encephalomyocarditis virus ribonucleic acid.J Virol. 1972 Mar;9(3):559-61 PMID: 4335665
-
Gene order of encephalomyocarditis virus as determined by studies with pactamycin.J Virol. 1972 May;9(5):823-8 PMID: 4337167
-
Cleavage of viral precursor proteins in vivo and in vitro.J Virol. 1972 Oct;10(4):751-9 PMID: 4343549
-
Inhibition of cleavage of large poliovirus-specific precursor proteins in infected HeLa cells by inhibitors of proteolytic enzymes.J Virol. 1972 Oct;10(4):880-4 PMID: 4343551
-
Kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins.Virology. 1972 Nov;50(2):535-49 PMID: 4344195
-
Mechanism of Mengo virus-induced cell injury in L cells: use of inhibitors of protein synthesis to dissociate virus-specific events.J Virol. 1972 Nov;10(5):969-78 PMID: 4344257
-
Initiation of picornavirus protein synthesis in ascites cell extracts.Proc Natl Acad Sci U S A. 1972 Dec;69(12):3589-93 PMID: 4345505
-
Protein synthesis directed by encephalomyocarditis virus mRNA. 3. Discrete polypeptides translated from a monocistronic messenger in vitro.Arch Biochem Biophys. 1972 Dec;153(2):706-13 PMID: 4350807
-
Structure of the Mengo virion. I. Polypeptide and ribonucleate components of the virus particle.Virology. 1974 Feb;57(2):531-42 PMID: 4361459
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