Epstein-Barr virus. Heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes.

The Journal of experimental medicine ·Vol. 137 ·No. 1 ·1973-01-01 ·Pages 140-7

Shope T, Miller G

Abstract

Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane.

MeSH Terms

Animals Antibodies, Heterophile/analysis Antibody Formation Antibody Specificity Antigens, Heterophile Cell Fractionation Cell Line Cell Membrane/immunology Complement Fixation Tests Female Fluorescent Antibody Technique Haplorhini Herpesvirus 4, Human/immunology Infectious Mononucleosis/immunology Lymphocyte Activation Lymphocyte Transfusion Time Factors Transplantation, Autologous

Chemicals

Antibodies, Heterophile Antigens, Heterophile

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Shope T

Miller G

References (12)

12 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.137.1.140

Published

1973-01-01

Pages

140-7

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139357

Subset

External Links

PubMed source DOI: 10.1084/jem.137.1.140 PMC Full Text View journal details

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Epstein-Barr virus. Heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes.

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