Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1 .

Journal of virology ·Vol. 8 ·No. 2 ·1971-08-00 ·Pages 215-24

Oxman MN, Levine AS, Crumpacker CS, Levin MJ, Henry PH, Lewis AM

Abstract

Ad2(+)ND(1), a nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, has been previously shown to contain a small segment of the SV40 genome covalently linked to Ad2 deoxyribonucleic acid (DNA). The SV40 portion of this hybrid virus has been characterized by relating the SV40-specific ribonucleic acid (RNA) sequences transcribed from the Ad2(+)ND(1) DNA to those transcribed from the DNA of SV40 itself. RNA-DNA hybridization-competition studies indicate that the SV40 component of Ad2(+)ND(1) consists of some, but not all, of that part of the SV40 genome which is transcribed early, i.e., prior to viral DNA replication, in SV40 lytic infection.

MeSH Terms

Adenoviridae/analysis Animals Antigens, Viral/analysis Base Sequence Carbon Isotopes Cell Line Culture Techniques DNA Replication DNA, Viral/biosynthesis,isolation & purification Genetic Code Genetics, Microbial Haplorhini Humans Hybridization, Genetic Kidney Nucleic Acid Hybridization RNA, Viral/analysis,isolation & purification Simian virus 40/analysis,immunology,pathogenicity Thymidine Virus Cultivation

Chemicals

Antigens, Viral Carbon Isotopes DNA, Viral RNA, Viral Thymidine

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Oxman M N

Levine A S

Crumpacker C S

Levin M J

Henry P H

Lewis A M

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38 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.8.2.215-224.1971

Published

1971-08-00

Pages

215-24

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356233

Subset

External Links

PubMed source DOI: 10.1128/JVI.8.2.215-224.1971 PMC Full Text View journal details

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Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1 .

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