The regulation of xanthine oxidase. Inhibition by reduced nicotinamide-adenine dinucleotide of rat liver xanthine oxidase type D and of chick liver xanthine dehydrogenase.

The Biochemical journal ·Vol. 117 ·No. 1 ·1970-03-00 ·Pages 97-100

Della Corte E, Stirpe F

Abstract

1. Rat liver xanthine oxidase type D (NAD(+)-dependent) and chick liver xanthine oxidase are inhibited by NADH, which competes with NAD(+). 2. The addition of a NADH-reoxidizing system in the assay of these enzyme activities is proposed. 3. Rat liver xanthine oxidase type O (oxygen-dependent) is not affected by NADH.

MeSH Terms

Animals Biological Assay Chickens Kinetics Liver/enzymology NAD/pharmacology Oxygen Rats Xanthine Oxidase/antagonists & inhibitors

Chemicals

NAD Xanthine Oxidase Oxygen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Della Corte E

Stirpe F

References (16)

16 references, click to expand

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J Biol Chem. 1960 Mar;235:819-24 PMID: 14413813
NADH oxidation by hypoxanthine dehydrogenase of avian kidney.
Biochim Biophys Acta. 1967 Sep 6;143(2):429-31 PMID: 4292892
STUDIES ON AVIAN XANTHINE DEHYDROGENASES. PROPERTIES AND PATTERNS OF APPEARANCE DURING DEVELOPMENT.
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Nature. 1958 Jan 4;181(4601):51-2 PMID: 13493594
The mechanism of dietary alterations in rat hepatic xanthine oxidase levels.
J Biol Chem. 1966 Dec 10;241(23):5571-6 PMID: 5928198
Chemistry and biochemistry of xanthine oxidase.
Adv Enzymol Relat Subj Biochem. 1956;17:293-328 PMID: 13313312
Purification and properties of chicken liver xanthine dehydrogenase.
J Biol Chem. 1967 Sep 25;242(18):4097-107 PMID: 4294045
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Biochem J. 1939 Oct;33(10):1694-708 PMID: 16747086
Studies on plant amylases: The effect of starch concentration upon the velocity of hydrolysis by the amylase of germinated barley.
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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1170097

Published

1970-03-00

Pages

97-100

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1178835

Subset

External Links

PubMed source DOI: 10.1042/bj1170097 PMC Full Text View journal details

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The regulation of xanthine oxidase. Inhibition by reduced nicotinamide-adenine dinucleotide of rat liver xanthine oxidase type D and of chick liver xanthine dehydrogenase.

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