Mengovirus-induced cytopathic effect in L-cells: protective effect of interferon.

Journal of virology ·Vol. 4 ·No. 4 ·1969-10-00 ·Pages 490-5

Haase AT, Levy H, Baron S, Kasel JA

Abstract

The effect of interferon on mengovirus-induced cytopathic effect (CPE) in L cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. CPE and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%.

MeSH Terms

Animals Carbon Isotopes Cycloheximide/pharmacology Cytopathogenic Effect, Viral/drug effects Encephalomyocarditis virus/growth & development,pathogenicity In Vitro Techniques Interferons/pharmacology L Cells/drug effects Lysosomes/physiopathology Mice Protein Biosynthesis Valine Viral Interference

Chemicals

Carbon Isotopes Interferons Cycloheximide Valine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Haase A T

Levy H

Baron S

Kasel J A

References (16)

16 references, click to expand

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Molecular basis of interferon action: inhibition of viral RNA translation.
Virology. 1966 Nov;30(3):502-16 PMID: 5950822
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Virology. 1967 Jun;32(2):184-200 PMID: 4290639
Concerning the mechanism of action of interferon.
Proc Natl Acad Sci U S A. 1966 Aug;56(2):558-65 PMID: 5229977
Some factors affecting the interferon-induced antiviral state.
Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1320-6 PMID: 4167135
Molecular basis of the action of interferon.
J Mol Biol. 1968 Feb 14;31(3):561-77 PMID: 4295315
The prevention of early vaccinia-virus-induced cytopathic effects by inhibition of protein synthesis.
J Gen Virol. 1968 Jul;3(1):51-61 PMID: 4234470
Destruction of L cells by Mengo virus: use of interferon to study the mechanism.
J Virol. 1968 Jun;2(6):567-75 PMID: 4301505
Inhibition of HeLa cell protein synthesis by the vaccinia virion.
J Virol. 1968 Oct;2(10):1028-37 PMID: 5723706
Alteration plaque morphology of EMC virus with polycations.
Virology. 1961 Aug;14:502-4 PMID: 13762015
MENGOVIRUS-INDUCED INHIBITION OF HOST RIBONUCLEIC ACID AND PROTEIN SYNTHESIS.
Biochim Biophys Acta. 1963 Nov 22;76:425-30 PMID: 14097404
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Virology. 1964 Apr;22:575-9 PMID: 14166118
CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.
Science. 1964 Dec 11;146(3650):1474-6 PMID: 14208575
HISTOCHEMICAL STUDIES OF LYSOSOMES AND LYSOSOMAL ENZYMES IN VIRUS-INFECTED CELL CULTURES.
J Exp Med. 1965 Mar 1;121:463-76 PMID: 14270244
CIRCULATING INTERFERON IN MICE AFTER INTRAVENOUS INJECTION OF VIRUS.
Science. 1963 Sep 13;141(3585):1061-3 PMID: 14043352
STUDIES ON THE MECHANISM OF POLIOVIRUS-INDUCED CELL DAMAGE. I. THE RELATION BETWEEN POLIOVIRUS,-INDUCED METABOLIC AND MORPHOLOGICAL ALTERATIONS IN CULTURED CELLS.
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.4.4.490-495.1969

Published

1969-10-00

Pages

490-5

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375898

Subset

External Links

PubMed source DOI: 10.1128/JVI.4.4.490-495.1969 PMC Full Text View journal details

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Mengovirus-induced cytopathic effect in L-cells: protective effect of interferon.

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