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PMID: 429552 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

The Journal of clinical investigation ·Vol. 63 ·No. 2 ·1979-02-00 ·Pages 268-75

Schroeder WA, Huisman TH, Efremov GD, Shelton JR, Shelton JB, Phillips R, Reese A, Gravely M, Harrison JM, Lam H

Abstract

A further study of the Tgamma-chain in a variety of conditions has revealed its presence in the cord bloods of ethnic groups previously unstudied. Heterozygous newborn average 17-19% Tgamma-chain while the mean value in four presumed homozygotes was 31%. The Tgamma-chain is readily detectable in beta-thalassemia of various ethnic groups (although infrequent in Blacks) as well as in deltabeta-thalassemia. Studies of a few families have provided an opportunity to determine whether or not certain individuals are heterozygous or homozygous for the Tgamma-gene. The Tgamma-chain has not been detected in the human fetal hemoglobin that is synthesized in increased amounts in persons with the hereditary persistence of fetal hemoglobin. Although the Tgamma-chain is detectable in sickle cell anemia, its frequency appears to be lower than in normal individuals. By focusing upon the relationship of the percentage of Tgamma-chain to the sources of human fetal globulin from determinants in cis and in trans, the conclusion has been reached that the Tgamma-chain is the product of a mutant Agamma-locus which should be named the TAgamma-chain.

MeSH Terms

Adult Anemia, Sickle Cell/blood Chemical Phenomena Chemistry Female Fetal Blood/analysis Fetal Hemoglobin/genetics Hemoglobins, Abnormal Humans Infant, Newborn Male Pedigree Racial Groups Thalassemia/blood,genetics

Chemicals

Hemoglobins, Abnormal Fetal Hemoglobin

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Schroeder W A

Huisman T H

Efremov G D

Shelton J R

Shelton J B

Phillips R

Reese A

Gravely M

Harrison J M

Lam H

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20 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI109299

Published

1979-02-00

Pages

268-75

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC371949

Subset

External Links

PubMed source DOI: 10.1172/JCI109299 PMC Full Text View journal details

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Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

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