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PMID: 751647 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The V gamma chain of fetal hemoglobin of the orangutan.

Biochemical genetics ·Vol. 16 ·No. 11-12 ·1978-12-00 ·Pages 1203-5

Schroeder WA, Shelton JR, Shelton JB, Huisman TH

Abstract

Previous studies suggested that orangutans have nonallelic structural genes for their gamma chains, because either a threonyl or an alanyl residue may occupy position 135. Further investigation has now detected that position 75 may have either an isoleucyl or a valyl residue. From available evidence, the isoleucyl and threonyl residues are in one chain an the valyl and alanyl in the other. Orangutans appear to be homozygous for the two types of nonallelic genes.

MeSH Terms
Amino Acid Sequence Animals Fetal Hemoglobin/genetics Genes Hominidae/blood Peptide Fragments/analysis Protein Precursors/analysis,genetics
Chemicals
Peptide Fragments Protein Precursors Fetal Hemoglobin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schroeder W A
Shelton J R
Shelton J B
Huisman T H
References (5)
5 references, click to expand
  1. Significance of a new type of human fetal hemoglobin carrying a replacement isoleucine replaced by threonine at position 75 )E 19) of the gamma chain.
    Hum Genet. 1976 Jun 29;32(3):305-13 PMID: 939551
  2. Search for nonallelic structural genes for gamma-chains of fetal hemoglobin in some primates.
    Biochem Genet. 1973 Nov;10(3):309-18 PMID: 4201857
  3. The T gamma chain of human fetal hemoglobin at birth and in several abnormal hematologic conditions.
    Pediatr Res. 1977 Oct;11(10 Pt 2):1102-5 PMID: 904975
  4. Chimpanzee foetal haemoglobin: structure and heterogeneity of the gamma chain.
    Biochim Biophys Acta. 1971 Nov 19;251(2):217-26 PMID: 11452387
  5. Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin.
    Proc Natl Acad Sci U S A. 1968 Jun;60(2):537-44 PMID: 5248810
Article Info
Journal
Biochemical genetics
Abbr.
Biochem Genet
ISSN
0006-2928
DOI
10.1007/BF00484540
Published
1978-12-00
Pages
1203-5
Language
English
Region
United States
NLM ID
0126611
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00484540 View journal details
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