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PMID: 4259667 Published · ppublish English Journal Article

Disease accompanying in utero viral infection. The role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus.

The Journal of experimental medicine ·Vol. 135 ·No. 4 ·1972-04-01 ·Pages 827-38

Oldstone MB, Dixon FJ

Abstract

Early, after in utero infection with LCM virus, SWR/J and HA/ICR mice developed manifestations of immune complex disease. Observations based on nursing such mice with virus-infected, immune, or noninfected mouse mothers indicated that maternal antiviral antibody was responsible for the early immune complex glomerulonephritis. Despite comparable viral persistance, in utero-infected offspring failed to develop glomerulonephritis when nursed by noninfected mouse mothers, but did when suckled by virus-infected mouse mothers. Nursing by mouse mothers carrying high titers of anti-LCM viral antibody markedly enhanced the Ig glomerular deposits and the resultant nephritis.

MeSH Terms
Animals Antigen-Antibody Complex Female Fetal Diseases/immunology Fluorescent Antibody Technique Glomerulonephritis/immunology Immune Complex Diseases/immunology Immunoglobulins Kidney Glomerulus/immunology Lymphocytic Choriomeningitis/immunology Lymphocytic choriomeningitis virus/immunology Maternal-Fetal Exchange Mice Milk Pregnancy Pregnancy Complications, Infectious/immunology
Chemicals
Antigen-Antibody Complex Immunoglobulins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oldstone M B
Dixon F J
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43 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.135.4.827
Published
1972-04-01
Pages
827-38
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139158
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.135.4.827 PMC Full Text View journal details
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