Induction of partial immunologic tolerance in rats and progressive loss of cellular antigenicity in Gross virus lymphoma.

The Journal of experimental medicine ·Vol. 139 ·No. 6 ·1974-06-01 ·Pages 1382-94

Ioachim HL, Keller SE, Dorsett BH, Pearse A

Abstract

Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis.

MeSH Terms

AKR murine leukemia virus/immunology Animals Animals, Newborn Antigens, Neoplasm/analysis Bromodeoxyuridine/pharmacology Cell Membrane/immunology Clone Cells/drug effects Complement Fixation Tests Cytoplasm/immunology Cytotoxicity Tests, Immunologic Fluorescent Antibody Technique Immune Tolerance Immunodiffusion Lymphoma/immunology Microscopy, Electron Neoplasm Transplantation Neoplasms, Experimental/immunology RNA Viruses/growth & development Rats Rats, Inbred WF Thymus Gland/immunology Transplantation, Homologous Virus Replication

Chemicals

Antigens, Neoplasm Bromodeoxyuridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ioachim H L

Keller S E

Dorsett B H

Pearse A

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26 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.139.6.1382

Published

1974-06-01

Pages

1382-94

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139688

Subset

External Links

PubMed source DOI: 10.1084/jem.139.6.1382 PMC Full Text View journal details

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Induction of partial immunologic tolerance in rats and progressive loss of cellular antigenicity in Gross virus lymphoma.

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