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PMID: 4550501 Published · ppublish English Journal Article

The antibody response of mice to murine leukemia virus in spontaneous infection: absence of classical immunologic tolerance (AKR mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 1 ·1972-01-00 ·Pages 134-8

Oldstone MB, Aoki T, Dixon FJ

Abstract

Gross murine leukemia virus is the etiologic agent of spontaneous leukemias of AKR mice. Despite the persistence of the Gross virus throughout their life, these mice are not immunologically tolerant to the virus. Specific antibodies to Gross antigens can be detected in the kidney where they have been deposited in the glomeruli, apparently in the form of Gross antigen-antibody complexes.

MeSH Terms
AKR murine leukemia virus/immunology Animals Antibody Formation Antigen-Antibody Complex Antigen-Antibody Reactions Antigens, Viral Complement Fixation Tests Erythrocytes/immunology Female Fluorescent Antibody Technique Immune Sera Immune Tolerance Kidney Glomerulus/immunology Leukemia/immunology Male Mice Mice, Inbred Strains Rats Species Specificity
Chemicals
Antigen-Antibody Complex Antigens, Viral Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Oldstone M B
Aoki T
Dixon F J
References (33)
33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.1.134
Published
1972-01-00
Pages
134-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC427561
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.1.134 PMC Full Text View journal details
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