Home LiteratureArticle Details
PMID: 4193936 Published · ppublish English Journal Article

Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera.

The Journal of experimental medicine ·Vol. 131 ·No. 4 ·1970-04-01 ·Pages 817-31

Gewurz H, Pickering RJ, Snyderman R, Lichtenstein LM, Good RA, Mergenhagen SE

Abstract

Bacterial lipopolysaccharides (LPS) derived from a variety of organisms effectively induced C consumption in humans, bovines, and porcines with developmental agammaglobulinemia; birds with experimental agammaglobulinemia; and humans with agammaglobulinemia syndromes. This interaction proceeded even in precolostral piglet sera which contained less than 2.5 x 10(-6) mg/ml gamma globulin, and led to generation of neutrophil chemotactic factor and anaphylatoxin in these sera. Hence, the LPS-C interaction can proceed in sera markedly deficient in immunoglobulin. The question of whether immunoglobulins can be bypassed in the LPS-C interaction, or whether they are regularly utilized in a way so efficient that their participation is masked, was considered.

MeSH Terms
Agammaglobulinemia/immunology,metabolism Animals Antibody Formation Antigen-Antibody Reactions Cattle Chickens Complement Fixation Tests Complement System Proteins/analysis,metabolism Hemolysin Proteins/analysis Humans Infant, Newborn Lipopolysaccharides/metabolism Neutralization Tests Rabbits Serratia/immunology Sheep Swine Venoms/isolation & purification gamma-Globulins/analysis
Chemicals
Hemolysin Proteins Lipopolysaccharides Venoms gamma-Globulins Complement System Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Gewurz H
Pickering R J
Snyderman R
Lichtenstein L M
Good R A
Mergenhagen S E
References (30)
30 references, click to expand
  1. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena.
    Science. 1954 Aug 20;120(3112):279-85 PMID: 13186838
  2. The conversion of C'IS to C'1 esterase by plasmin and trypsin.
    J Exp Med. 1967 Feb 1;125(2):337-58 PMID: 4225264
  3. Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.
    Clin Exp Immunol. 1968 Jun;3(5):437-45 PMID: 5662582
  4. Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes.
    J Exp Med. 1968 Aug 1;128(2):259-75 PMID: 4873021
  5. The action of endotoxin on complement.
    Folia Microbiol (Praha). 1962 May;7:191-2 PMID: 14458728
  6. Ontogeny of the immune response. I. Development of immunoglobulins in germfree and conventional colostrum-deprived piglets.
    J Immunol. 1966 Jul;97(1):52-63 PMID: 4162439
  7. Interactions of the complement system with endotoxins from a Salmonella minnesota mutant deficient in O-polysaccharide and heptose.
    J Immunol. 1968 Jan;100(1):227-9 PMID: 5635624
  8. The ontogeny of complement activity. Complement titers in the developing chick embryo during graft-versus-host reactions.
    Proc Soc Exp Biol Med. 1966 Dec;123(3):718-21 PMID: 5959010
  9. Quantitative studies of the properdin-complement system. III. Kinetics of the reaction between C'3 and the properdin-zymosan complex.
    J Immunol. 1958 Jul;81(1):23-8 PMID: 13563875
  10. Complement activity and inflammatory neutrophil exudation in man. Studies in patients with glomerulonephritis, essential hypocomplementemia and agammaglobulinemia.
    Int Arch Allergy Appl Immunol. 1967;32(1):64-90 PMID: 4864667
  11. ANTICOMPLEMENTARY ACTION OF ENDOTOXIN.
    Proc Soc Exp Biol Med. 1964 Dec;117:639-43 PMID: 14244914
  12. Interactions of the complement system with native and chemically modified endotoxins.
    J Bacteriol. 1968 Feb;95(2):397-405 PMID: 4170751
  13. Lymphopenic forms of congenital immunologic deficiency diseases.
    Medicine (Baltimore). 1968 May;47(3):201-26 PMID: 4874818
  14. Non specific hemolysis of erythrocytes modified with bacterial endotoxins.
    Ann Inst Pasteur (Paris). 1965 Jul;109(1):66-79 PMID: 5847937
  15. Immunochemical quantitation of antigens by single radial immunodiffusion.
    Immunochemistry. 1965 Sep;2(3):235-54 PMID: 4956917
  16. Role of antibodies in reactions to gram-negative bacterial endotoxins.
    Ann N Y Acad Sci. 1966 Jun 30;133(2):727-45 PMID: 4164248
  17. Interactions of the complement system with endotoxic lipopolysaccharide: the generation of an anaphylatoxin.
    Immunology. 1969 Mar;16(3):327-36 PMID: 4388903
  18. Significance of complement to the mechanism of action of endotoxin.
    Curr Top Microbiol Immunol. 1969;50:37-77 PMID: 4907133
  19. A molecular concept of immune cytolysis.
    Arch Pathol. 1966 Sep;82(3):205-17 PMID: 5329367
  20. Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes.
    Proc Soc Exp Biol Med. 1969 May;131(1):203-7 PMID: 5770101
  21. Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components.
    J Exp Med. 1968 Nov 1;128(5):1049-57 PMID: 4176223
  22. Complement and complement component activities in diseases associated with repeated infections and malignancy.
    Int Arch Allergy Appl Immunol. 1968;33(4):368-88 PMID: 5689777
  23. A plasmin-split fragment of C'3 as a new chemotactic factor.
    J Exp Med. 1967 Aug 1;126(2):189-206 PMID: 4226271
  24. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  25. Ontogenetic development of the complement system.
    Immunology. 1969 Mar;16(3):319-26 PMID: 4181538
  26. THE ROLE OF THE COMPONENTS OF COMPLEMENT IN SPECIFIC IMMUNE FIXATION.
    J Exp Med. 1942 Apr 1;75(4):421-35 PMID: 19871194
  27. Interactions of the complement system with the surface and endotoxic lipopolysaccharide of Veillonella alcalescens.
    J Exp Med. 1967 May 1;125(5):767-86 PMID: 4164691
  28. Passive hemolysis by serum and cobra venom factor: a new mechanism inducing membrane damage by complement.
    Proc Natl Acad Sci U S A. 1969 Feb;62(2):521-7 PMID: 4978744
  29. A new concept of immunosuppression in hypersensitivity reactions and in transplantation immunity.
    Surv Ophthalmol. 1966 Aug;11(4):498-505 PMID: 5919620
  30. THE PATHOGENESIS OF IMMUNOLOGIC DEFICIENCY DISEASES.
    Am J Med. 1965 Apr;38:579-604 PMID: 14271744
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.131.4.817
Published
1970-04-01
Pages
817-31
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138773
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.131.4.817 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2