Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 282 ·No. 3 ·1974-00-00 ·Pages 295-306

Wagner J, Reinhardt D

Abstract

暂无摘要

MeSH Terms

Adrenergic alpha-Antagonists/pharmacology Adrenergic beta-Antagonists/pharmacology Animals Electric Stimulation Guinea Pigs Heart/drug effects Heart Atria Heart Rate/drug effects In Vitro Techniques Male Methoxamine/pharmacology Naphazoline/pharmacology Oxymetazoline/pharmacology Perfusion Phentolamine/pharmacology Phenylephrine/antagonists & inhibitors,pharmacology Pindolol/pharmacology Rabbits Receptors, Adrenergic/drug effects Reserpine/pharmacology Stimulation, Chemical

Chemicals

Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Receptors, Adrenergic Phenylephrine Reserpine Oxymetazoline Pindolol Naphazoline Methoxamine Phentolamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wagner J

Reinhardt D

References (13)

13 references, click to expand

Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.
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Blockade of the cardiac action of phenylephrine by bretylium or cocaine.
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Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.
J Pharmacol Exp Ther. 1968 Jan;159(1):82-90 PMID: 4384517
The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines.
J Med Chem. 1966 May;9(3):273-80 PMID: 5960887
Effects of isoprenaline and phenylephrine on energy-rich phosphate compounds and glucose-6-phosphate in smooth and cardiac muscle.
Br J Pharmacol. 1971 Nov;43(3):593-603 PMID: 5157725
Influence of the metabolic state on the action of phenylephrine on rabbit ileum, guinea-pig vas deferens and atrium.
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(1):63-70 PMID: 4266251
Pharmacological characteristics of adrenergic receptors.
Fed Proc. 1970 Jul-Aug;29(4):1352-61 PMID: 4394100
A positive inotropic effect of phenylephrine mediated through alpha adrenergic receptors.
Life Sci. 1967 Jul 1;6(13):1361-5 PMID: 4382450
Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.
Arch Int Pharmacodyn Ther. 1963;143:299-330 PMID: 13996119
Influence of temperature on the sensitivity of the -receptors and the contractility of guinea-pig atrium.
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):95-104 PMID: 4404649
Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.
Br J Pharmacol Chemother. 1967 Aug;30(3):603-11 PMID: 6058154
Effect of phenylephrine on cardiac contractility and adenyl cyclase activity.
Can J Physiol Pharmacol. 1971 Jun;49(6):508-12 PMID: 4326029
Characterization of -adrenoceptors in the myocardium.
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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00501237

Published

1974-00-00

Pages

295-306

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00501237 View journal details

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Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs.

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