Home LiteratureArticle Details
PMID: 4146762 Published · ppublish English Journal Article

Characterization of -adrenoceptors in the myocardium.

British journal of pharmacology ·Vol. 48 ·No. 1 ·1973-05-00 ·Pages 132-8

Benfey BG

Abstract

1. In the driven rabbit left atrium alpha-adrenoceptors mediate the inotropic effect of phenylephrine and the prolongation of functional refractory period by sympathomimetic amines.2. These receptors are highly sensitive to blockade by phentolamine and phenoxybenzamine.3. Prolongation of functional refractory period is greater with the secondary amines, phenylephrine, adrenaline and epinine, than with the primary amines, norphenylephrine, noradrenaline and dopamine.

MeSH Terms
Adrenergic alpha-Agonists/pharmacology Adrenergic beta-Agonists/pharmacology Adrenergic beta-Antagonists/pharmacology Animals Cocaine/pharmacology Dose-Response Relationship, Drug Electric Stimulation Heart/drug effects Heart Atria/drug effects In Vitro Techniques Methoxamine/pharmacology Myocardium/metabolism Phenoxybenzamine/pharmacology Phenylephrine/pharmacology Rabbits Receptors, Adrenergic/drug effects Refractory Period, Electrophysiological/drug effects Reserpine/pharmacology Sympathomimetics/pharmacology
Chemicals
Adrenergic alpha-Agonists Adrenergic beta-Agonists Adrenergic beta-Antagonists Receptors, Adrenergic Sympathomimetics Phenoxybenzamine Phenylephrine Reserpine Methoxamine Cocaine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Benfey B G
References (17)
17 references, click to expand
  1. Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.
    Arch Int Pharmacodyn Ther. 1966 Apr;160(2):379-89 PMID: 4380923
  2. Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes.
    J Pharmacol Exp Ther. 1966 Nov;154(2):255-63 PMID: 4380741
  3. Prolongation of the myocardial functional refractory period by phenylephrine.
    Life Sci. 1967 Jul 1;6(13):1367-71 PMID: 6035765
  4. The pharmacological differentiation of adrenergic receptors.
    Ann N Y Acad Sci. 1967 Feb 10;139(3):553-70 PMID: 5232334
  5. Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.
    Br J Pharmacol Chemother. 1967 Aug;30(3):603-11 PMID: 6058154
  6. Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.
    J Pharmacol Exp Ther. 1968 Jan;159(1):82-90 PMID: 4384517
  7. Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria.
    J Pharmacol Exp Ther. 1969 Dec;170(2):262-71 PMID: 4391006
  8. Blockade of the cardiac action of phenylephrine by bretylium or cocaine.
    J Pharmacol Exp Ther. 1970 Apr;172(2):274-81 PMID: 5441156
  9. Effect of phenylephrine on cardiac contractility and adenyl cyclase activity.
    Can J Physiol Pharmacol. 1971 Jun;49(6):508-12 PMID: 4326029
  10. The adrenergic receptors of the coronary circulation in the isolated dog heart.
    Arch Int Pharmacodyn Ther. 1969 Oct;181(2):328-42 PMID: 4397537
  11. Phenylephrine effects on cardiac contractility adenyl cyclase, and phosphorylase.
    Arch Int Pharmacodyn Ther. 1972 Jun;197(2):317-27 PMID: 4337939
  12. Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines.
    Br J Pharmacol. 1971 Dec;43(4):757-63 PMID: 4339883
  13. MODIFICATION BY RESERPINE OF THE RESPONSE OF THE ATRIAL PACEMAKER TO SYMPATHOMIMETIC AMINES.
    J Pharmacol Exp Ther. 1963 Sep;141:301-9 PMID: 14064191
  14. THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY.
    Pharmacol Rev. 1963 Sep;15:601-52 PMID: 14064358
  15. THE NATURE OF THE ANTAGONISM BY METHOXAMINE OF THE CHRONOTROPIC AND INOTROPIC EFFECTS OF CATECHOLAMINES.
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 Apr 21;248:73-84 PMID: 14194527
  16. MECHANISM OF CARDIAC ACTIVITIES SYMPATHOMIMETIC AMINES ON ISOLATED AURICLES OF RABBITS.
    Arch Int Pharmacodyn Ther. 1964 Sep 1;151:93-110 PMID: 14205430
  17. A positive inotropic effect of phenylephrine mediated through alpha adrenergic receptors.
    Life Sci. 1967 Jul 1;6(13):1361-5 PMID: 4382450
Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1973.tb08230.x
Published
1973-05-00
Pages
132-8
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1776086
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1973.tb08230.x PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2