Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines.

British journal of pharmacology ·Vol. 43 ·No. 4 ·1971-12-00 ·Pages 757-63

Benfey BG

Abstract

1. Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines.

MeSH Terms

Adenylyl Cyclases/metabolism Animals Cyclic AMP/metabolism Dopamine/pharmacology Heart/drug effects In Vitro Techniques Muscle Contraction/drug effects Myocardium/enzymology,metabolism Norepinephrine/pharmacology Phenylephrine/pharmacology Rabbits Stimulation, Chemical Sympathomimetics/pharmacology Tritium

Chemicals

Sympathomimetics Tritium Phenylephrine Cyclic AMP Adenylyl Cyclases Dopamine Norepinephrine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Benfey B G

References (12)

12 references, click to expand

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Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.
Arch Int Pharmacodyn Ther. 1966 Apr;160(2):379-89 PMID: 4380923
Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.
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An assay for adenyl cyclase.
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Effects of epinephrine on cardiac cyclic 3',5'-AMP, phosphorylase kinase, and phosphorylase.
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A simple, sensitive method for the assay of adenyl cyclase.
J Pharmacol Exp Ther. 1968 Oct;163(2):379-85 PMID: 4300679
Hormonal regulation of myocardial adenosine 3',5'-monophosphate.
Biochim Biophys Acta. 1969 Apr 1;177(2):189-95 PMID: 4305360
Pharmacological characteristics of adrenergic receptors.
Fed Proc. 1970 Jul-Aug;29(4):1352-61 PMID: 4394100
The adrenergic receptors of the coronary circulation in the isolated dog heart.
Arch Int Pharmacodyn Ther. 1969 Oct;181(2):328-42 PMID: 4397537
MECHANISM OF CARDIAC ACTIVITIES SYMPATHOMIMETIC AMINES ON ISOLATED AURICLES OF RABBITS.
Arch Int Pharmacodyn Ther. 1964 Sep 1;151:93-110 PMID: 14205430
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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1971.tb07211.x

Published

1971-12-00

Pages

757-63

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1665713

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1971.tb07211.x PMC Full Text View journal details

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Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines.

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