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PMID: 4137938 Published · ppublish English Journal Article

Specificity of the DNA product of RNA-dependent DNA polymerase in type C viruses: 3. Analysis of viruses derived from Syrian hamsters.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 8 ·1974-08-00 ·Pages 3278-82

Okabe H, Gilden RV, Hatanaka M

Abstract

DNA transcripts were prepared from three related viruses of hamster and analyzed by interviral hybridization and by reaction with cellular DNA. A virus (G-HaLV), isolated from a dimethylbenzanthraceneinduced tumor cell in Graffi hamsters, contained nucleic acid sequences highly specific for hamster cell DNA and did not react with mouse cell DNA nor did its transcript show homology (<5%) with mouse or rat viral RNAs. The hamster-specific sarcoma virus, B-34, isolated by Bassin and coworkers from tumors induced by the Harvey strain of murine sarcoma virus, contained mouse-, hamster-, and possibly rat-specific sequences. B-34 transcripts were predominantly mouse-specific. GLOH(-), a lymphomagenic virus derived by dilution beyond the transforming endpoint of a hamster-specific sarcoma virus obtained from tumors induced by the Gross pseudotype of murine sarcoma virus, also contained hamster- and mouse-specific sequences. Only a portion of its hamster sequence (about 50%) was shared with B-34 and G-HaLV viruses. As expected, transcripts of GLOH(-) virus were reactive with mouse and hamster cellular DNA.

MeSH Terms
Animals Cell Transformation, Neoplastic Cricetinae DNA/analysis,biosynthesis DNA, Single-Stranded/metabolism DNA, Viral/analysis,biosynthesis Nucleic Acid Hybridization Phenotype RNA, Messenger RNA, Viral/metabolism RNA-Directed DNA Polymerase/metabolism Retroviridae/enzymology,metabolism Species Specificity Transcription, Genetic Tritium
Chemicals
DNA, Single-Stranded DNA, Viral RNA, Messenger RNA, Viral Tritium DNA RNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Okabe H
Gilden R V
Hatanaka M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.8.3278
Published
1974-08-00
Pages
3278-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388668
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.8.3278 PMC Full Text View journal details
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