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PMID: 4333039 Published · ppublish English Journal Article

Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 1 ·1972-01-00 ·Pages 20-4

Varmus HE, Weiss RA, Friis RR, Levinson W, Bishop JM

Abstract

The effect of unlabeled cellular DNA upon the reassociation kinetics of labeled double-stranded DNA made by DNA polymerase from avian tumor viruses has been used to measure virus-specific nucleotide sequences in cells. Multiple copies of these sequences were found equally in normal chick cells, in chick cells transformed in culture, and in Rous tumor cells. Copies were also present equally in cells harboring chick helper factor and group-specific antigen, and in cells lacking those characteristics. Quail DNA also contains multiple copies of these sequences, but no copies were detected in HeLa-cell DNA or salmon-sperm DNA.

MeSH Terms
Animals Antigens, Viral Avian Sarcoma Viruses/metabolism Base Sequence Cells, Cultured Chick Embryo Chickens DNA Nucleotidyltransferases/metabolism DNA Replication DNA, Viral/biosynthesis,metabolism Diploidy Genetic Code In Vitro Techniques Phosphorus Isotopes Poultry RNA, Viral/metabolism Sarcoma, Avian/enzymology,metabolism Virus Replication
Chemicals
Antigens, Viral DNA, Viral Phosphorus Isotopes RNA, Viral DNA Nucleotidyltransferases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Varmus H E
Weiss R A
Friis R R
Levinson W
Bishop J M
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.1.20
Published
1972-01-00
Pages
20-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC427535
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.1.20 PMC Full Text View journal details
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