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PMID: 4011440 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Highly conserved sequences in the 3' untranslated region of mRNAs coding for homologous proteins in distantly related species.

Nucleic acids research ·Vol. 13 ·No. 10 ·1985-05-24 ·Pages 3723-37

Yaffe D, Nudel U, Mayer Y, Neuman S

Abstract

Comparison of the nucleotide sequence of mRNAs coding for several vertebrate actins revealed a high degree of sequence homology in the 3' untranslated region (3' UTR) between those mRNAs coding for homologous (isotypic) actins in different organisms but not between mRNAs coding for very similar isoforms differing in their function or tissue specificity. A similar pattern of sequence conservation in the 3' UTR is also found in several other genes. Furthermore, while there is a great variation in the size of the 3' UTR of mRNAs coding for different proteins, mRNA coding for isotypic proteins in distantly related organisms often have 3' UTR of similar size. The data suggest that the 3' UTR may play an important role in the regulation of expression of at least some genes at the transcriptional or posttranscriptional level.

MeSH Terms
Actins/genetics Animals Base Sequence Biological Evolution Gene Expression Regulation Globins/genetics Humans Muscles/analysis Myocardium/analysis Protein Biosynthesis RNA, Messenger/analysis Rats Tubulin/genetics
Chemicals
Actins RNA, Messenger Tubulin Globins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yaffe D
Nudel U
Mayer Y
Neuman S
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59 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.10.3723
Published
1985-05-24
Pages
3723-37
Language
English
Region
England
NLM ID
0411011
PMCID
PMC341269
Subset
IM
Grants
NIGMS NIH HHS · GM-22767 · United States
External Links
PubMed source DOI: 10.1093/nar/13.10.3723 PMC Full Text View journal details
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