Locations of bacteriophage T4 origins of replication.
Partially replicated bacteriophage T4 DNA containing cytosine was isolated from cells 6.5 and 7 min after infection and cleaved with restriction endonuclease BglII or BamHI. Positions of replication eyes relative to the cleavage sites were observed by electron microscopy. Four groups of eyes were found. They are consistent with replication from origins located at map positions 34, 60, 73, and 86 kilobases. In individual molecules that contained two or three eyes, the distribution of the eyes agreed with the initiation of replication at more than one of these four assigned origins and possibly at two additional origins located near 15 and 110 kilobases, which were reported by P. M. Macdonald, R. M. Seaby, W. Brown, and G. Mosig (p. 111-116, in D. Schlessinger, ed., Microbiology--1983, 1983) and M. E. Halpern, T. Mattson, and A. W. Kozinski (Proc. Natl. Acad. Sci. U.S.A. 76:6137-6141, 1979).
12 references, click to expand
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A preferred origin and direction of bacteriophage T4 DNA replication. I. A gradient of allele frequencies in crosses between normal and small T4 particles.J Mol Biol. 1970 Nov 14;53(3):503-14 PMID: 4924010
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Origin and direction of bacteriophage T4 DNA replication. II. A gradient of marker frequencies in partially replicated T4 DNA as assayed by transformation.J Mol Biol. 1971 Sep 14;60(2):213-33 PMID: 4938732
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Structure of the replicating DNA from bacteriophage T4.Proc Natl Acad Sci U S A. 1971 Dec;68(12):3049-53 PMID: 4943552
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The patterns of recombination and segregation in terminal regions of T4DNA molecules.Mol Gen Genet. 1971;113(1):51-91 PMID: 4944481
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Electron microscope heteroduplex study of sequence relations of T2, T4, and T6 bacteriophage DNAs.Virology. 1974 Jan;57(1):93-111 PMID: 4594471
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A gene of bacteriophage T4 whose product prevents true late transcription on cytosine-containing T4 DNA.Proc Natl Acad Sci U S A. 1976 Sep;73(9):3098-102 PMID: 1067605
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Complete nucleotide sequence of the Escherichia coli plasmid pBR322.Cold Spring Harb Symp Quant Biol. 1979;43 Pt 1:77-90 PMID: 383387
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Origins of phage T4 DNA replication as revealed by hybridization to cloned genes.Proc Natl Acad Sci U S A. 1979 Dec;76(12):6137-41 PMID: 293710
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Map of restriction sites on bacteriophage T4 cytosine-containing DNA for endonucleases bamHI, BglII, KpnI, PvuI, SalI, and XbaI.J Virol. 1981 Apr;38(1):104-14 PMID: 6264096
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Identification of the origins of T4 DNA replication.Proc Natl Acad Sci U S A. 1982 Dec;79(23):7248-52 PMID: 6760193
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Early intermediates in bacteriophage T4 DNA replication and recombination.J Virol. 1983 Feb;45(2):813-31 PMID: 6834472
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