Linkage and recombination between fragile X-linked mental retardation and the factor IX gene.
Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest.
15 references, click to expand
-
The marker (X) syndrome: a cytogenetic and genetic analysis.Ann Hum Genet. 1984 Jan;48(Pt 1):21-37 PMID: 6712153
-
FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition.Am J Hum Genet. 1981 Mar;33(2):234-42 PMID: 6452060
-
Molecular cloning of the gene for human anti-haemophilic factor IX.Nature. 1982 Sep 9;299(5879):178-80 PMID: 6287289
-
Regional localization on the human X chromosome and polymorphism of the coagulation factor IX gene (hemophilia B locus).Proc Natl Acad Sci U S A. 1984 Jan;81(2):498-502 PMID: 6320191
-
Sequential tests for the detection of linkage.Am J Hum Genet. 1955 Sep;7(3):277-318 PMID: 13258560
-
Linkage analysis of X-linked mental retardation with and without fragile-X using factor IX gene probe.Lancet. 1984 Aug 11;2(8398):349 PMID: 6146889
-
Detection of specific sequences among DNA fragments separated by gel electrophoresis.J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
-
Isolation and characterization of a cDNA coding for human factor IX.Proc Natl Acad Sci U S A. 1982 Nov;79(21):6461-4 PMID: 6959130
-
Marker (X)-linked mental retardation.Adv Hum Genet. 1983;13:83-112 PMID: 6362362
-
Linkage analysis in man.Adv Hum Genet. 1980;10:209-66 PMID: 6994459
-
Isolation and characterization of human factor IX cDNA: identification of Taq I polymorphism and regional assignment.Somat Cell Mol Genet. 1984 Sep;10(5):465-73 PMID: 6089357
-
Expression of the marker (X) (q28) in lymphoblastoid cell lines.Am J Hum Genet. 1982 Jul;34(4):552-7 PMID: 6213152
-
X-linked mental retardation: a study of 7 families.Am J Med Genet. 1980;7(4):471-89 PMID: 7211957
-
Close linkage of fragile X-mental retardation syndrome to haemophilia B and transmission through a normal male.Nature. 1983 Dec 15-21;306(5944):701-4 PMID: 6689201
-
Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX.Nucleic Acids Res. 1983 Apr 25;11(8):2325-35 PMID: 6687940
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