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PMID: 3949240 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

Gut ·Vol. 27 ·No. 1 ·1986-01-00 ·Pages 78-85

Mitchell TJ, Ketley JM, Haslam SC, Stephen J, Burdon DW, Candy DC, Daniel R

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

MeSH Terms
Animals Bacterial Toxins/pharmacology Clostridium Colon/drug effects Cytotoxins/pharmacology Dose-Response Relationship, Drug Enterotoxins/pharmacology Ileum/drug effects Male Permeability Rabbits Time Factors
Chemicals
Bacterial Toxins Cytotoxins Enterotoxins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Mitchell T J
Ketley J M
Haslam S C
Stephen J
Burdon D W
Candy D C
Daniel R
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22 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.27.1.78
Published
1986-01-00
Pages
78-85
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1433160
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.27.1.78 PMC Full Text View journal details
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