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PMID: 172454 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum.

Infection and immunity ·Vol. 12 ·No. 5 ·1975-11-00 ·Pages 1214-8

McDonel JL, Duncan CL

Abstract

Highly purified enterotoxin from Clostridium perfringens was found to have histopathological activity in the rabbit ileum. Unlike the action of cholera, Escherichia coli, and Shigella enterotoxins, epithelium was denuded from the tips of ileal villi at concentrations of the enterotoxin necessary to induce fluid accumulation in the rabbit. Whether or not this observed histopathology is essential for the diarrheal syndrome associated with Clostridium perfringens food poisoning remains unclear.

MeSH Terms

Animals Biological Transport Clostridium perfringens Dose-Response Relationship, Drug Enterotoxins/pharmacology Epithelium/pathology Ileum/microbiology,pathology Rabbits

Chemicals

Enterotoxins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

McDonel J L

Duncan C L

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.12.5.1214-1218.1975

Published

1975-11-00

Pages

1214-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC415419

Subset

External Links

PubMed source DOI: 10.1128/iai.12.5.1214-1218.1975 PMC Full Text View journal details

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Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum.

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