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PMID: 3932823 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Suppression of defective-sporulation phenotypes by mutations in the major sigma factor gene (rpoD) of Bacillus subtilis.

Molecular & general genetics : MGG ·Vol. 201 ·No. 1 ·1985-00-00 ·Pages 96-8

Leung A, Rubinstein S, Yang C, Li JW, Leighton T

Abstract

Mutations (crsA47 and crsA4) in the major sigma factor gene (rpoD) of Bacillus subtilis RNA polymerase have been found to be powerful intergenic suppressors of spoOB, spoOE, spoOF, spoOK and spoIIG mutations. The crsA47 suppressor restores sporulation of spoOE, spoOF, spoOK and spoIIG mutants to levels near those of wild type bacteria and substantially improves the sporulation of a spoOB strain. The crsA mutations are shown to prevent the induction by aliphatic alcohols of SpoO phenocopies in wild type B. subtilis cells.

MeSH Terms
Bacillus subtilis/genetics Genes Genes, Bacterial Genotype Mutation Phenotype Sigma Factor/genetics Species Specificity Spores, Bacterial/physiology Suppression, Genetic Transcription Factors/genetics
Chemicals
Sigma Factor Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Leung A
Rubinstein S
Yang C
Li J W
Leighton T
References (11)
11 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00397992
Published
1985-00-00
Pages
96-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00397992
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