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PMID: 3927579 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus.

Virchows Archiv. A, Pathological anatomy and histopathology ·Vol. 407 ·No. 2 ·1985-00-00 ·Pages 119-49

Marino M, Müller-Hermelink HK

Abstract

Based on the light microscopical features of normal thymic epithelial cells, human thymoma was divided in different types, namely cortical, medullary, and mixed ones, according to the epithelial cell (EC) type. Lymphoid cell populations with morphological features of either cortical or medullary thymocytes were found according to different types of EC in thymoma. The histological variation of the different types of thymoma are demonstrated. In a retrospective study of 58 thymomas and 13 thymic carcinomas, malignant invasive character as well as the occurrence of myasthenia gravis were both found to be related to the neoplastic proliferation of the cortical epithelial cells, whereas in the usual mixed type of thymoma and the medullary type no gross invasion or metastases were noticed. These results are discussed in view of recent concepts and immunological findings of thymus microarchitecture.

MeSH Terms
Adolescent Adult Aged Cell Differentiation Child Child, Preschool Epithelium/pathology Female Humans Infant Lymphocytes/classification Male Middle Aged Myasthenia Gravis/complications Thymoma/classification,complications,pathology Thymus Gland/anatomy & histology,cytology Thymus Neoplasms/classification,complications,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marino M
Müller-Hermelink H K
References (59)
59 references, click to expand
  1. Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.
    J Clin Invest. 1983 Jan;71(1):9-14 PMID: 6336763
  2. Functional properties of human thymoma lymphocytes: role of subcellular factors in blastic activation.
    J Natl Cancer Inst. 1982 Oct;69(4):827-31 PMID: 6981722
  3. Thymoma: lymphoid and epithelial components mirror the phenotype of normal thymus.
    Hum Pathol. 1984 Apr;15(4):378-84 PMID: 6609116
  4. The T-cell nature of the lymphocytes in two human epithelial thymomas: a comparative immunologic, scanning and transmission electron microscopic study.
    Clin Immunol Immunopathol. 1975 Jul;4(2):199-208 PMID: 1095263
  5. Epithelio-reticular cell thymoma with lymphocytic "emperipolesis." An ultrastructural study.
    Cancer. 1975 Nov;36(5):1794-803 PMID: 1192365
  6. Thymoma: a clinicopathologic study.
    J Thorac Cardiovasc Surg. 1961 Oct;42:424-44 PMID: 13868094
  7. T cell maturation: thymocyte and thymus migrant subpopulations defined with monoclonal antibodies to MHC region antigens.
    J Immunol. 1980 Jun;124(6):2845-53 PMID: 6154739
  8. Microanatomy of the thymus: its relationship to T cell differentiation.
    Ciba Found Symp. 1981;84:161-77 PMID: 7023868
  9. Lymphocyte differentiation and its microenvironment in the human thymus during aging.
    Monogr Dev Biol. 1984;17:142-55 PMID: 6431270
  10. Epithelial nature of spindle-cell thymoma. An ultrastructural study.
    Cancer. 1972 Aug;30(2):500-11 PMID: 5051674
  11. Human thymoma: immunologic characteristics of the lymphocytic component.
    Cancer. 1981 Nov 1;48(9):1992-5 PMID: 7296508
  12. Ultrastructure of epithelial cells in the medulla of the guinea-pig thymus.
    Aust J Exp Biol Med Sci. 1968 Dec;46(6):755-67 PMID: 5729729
  13. Thymoma: factors influencing prognosis.
    Surg Clin North Am. 1973 Aug;53(4):885-92 PMID: 4717257
  14. A human thymoma with prothymocyte-like infiltration.
    Clin Immunol Immunopathol. 1983 Sep;28(3):350-60 PMID: 6603937
  15. Thymus related tumors and tumor-like lesions in childhood with rapid clinical progression and death.
    Hum Pathol. 1977 Jan;8(1):53-66 PMID: 844854
  16. Thymomas.
    Cancer. 1977 May;39(5):2142-57 PMID: 558046
  17. Thymoma: a clinical and pathological study of 65 cases.
    Cancer. 1976 Jan;37(1):229-49 PMID: 1247958
  18. Thymoma. Analysis of benign and malignant criteria.
    J Thorac Cardiovasc Surg. 1974 Feb;67(2):310-21 PMID: 4129835
  19. Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. Clinicopathologic study of 8 cases.
    Cancer. 1972 Apr;29(4):1061-74 PMID: 4111691
  20. Human thymoma lymphocyte mitogenesis: glucocorticoid inhibitory capacity as a function of the size of the more mature T cell subset.
    Clin Exp Immunol. 1983 Jun;52(3):477-84 PMID: 6603294
  21. Ultrastructure of the human thymus, thymic tumors, and myasthenia gravis.
    Pathol Annu. 1975;10:329-91 PMID: 241046
  22. The human thymus microenvironment: in vivo identification of thymic nurse cells and other antigenically-distinct subpopulations of epithelial cells.
    Immunology. 1981 Nov;44(3):439-46 PMID: 7033113
  23. PATHOLOGY AND CLINICAL BEHAVIOR OF THYMOMAS. A SURVEY OF 51 CASES.
    Cancer. 1965 Sep;18:1131-44 PMID: 14332543
  24. [A comparative clinical and pathological study on the classification and prognostic features of 57 thymomas. II. prognostic features (author's transl)].
    Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Jan 26;91(1):103-15 PMID: 146336
  25. The intrathymic microenvironment: expression of lectin receptors and lectin-like molecules of differentiation antigens and MHC gene products.
    Thymus. 1983 Sep;5(5-6):311-26 PMID: 6606875
  26. Thymic medullary lymphocytes. I. Lymphokines produced by thymic medullary lymphocytes as a second signal for intrathymic stem cell homing.
    Cell Immunol. 1982 Jan 15;66(2):233-9 PMID: 6461418
  27. Detection and distribution of alfa-naphthyl acetate esterase activity in thymocytes of normal, myasthenic thymus and thymoma. Histochemical and cytochemical study in relation to E-rosetting.
    Virchows Arch B Cell Pathol Incl Mol Pathol. 1980;35(1):33-43 PMID: 6111155
  28. Detection by S-100 immunolabelling of interdigitating reticulum cells in human thymomas.
    Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(2):187-95 PMID: 6143446
  29. Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic study.
    Histochemistry. 1974 Mar 27;39(1):25-34 PMID: 4135006
  30. Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization.
    J Exp Med. 1980 Apr 1;151(4):925-44 PMID: 6966312
  31. Thymic hyperplasia and neoplasia: a review of current concepts.
    Hum Pathol. 1978 Sep;9(5):495-515 PMID: 361541
  32. Thymoma immunological and ultrastructural characterization.
    Cancer. 1977 Apr;39(4):1455-61 PMID: 300647
  33. Immunohistochemical analysis of thymoma. Evidence for medullary origin of epithelial cells.
    Am J Surg Pathol. 1984 Apr;8(4):309-18 PMID: 6370000
  34. Primary thymic carcinomas.
    Am J Surg Pathol. 1982 Oct;6(7):613-30 PMID: 6295194
  35. Ontogeny and organization of the stationary non-lymphoid cells in the human thymus.
    Cell Tissue Res. 1980;207(2):287-306 PMID: 7388920
  36. Myosin and actin containing cells in the human postnatal thymus. Ultrastructural and immunohistochemical findings in normal thymus and in myasthenia gravis.
    Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Dec;32(1):33-45 PMID: 45151
  37. Thymoma: an immunologic and electron microscopic study.
    Cancer. 1978 Jun;41(6):2183-91 PMID: 306871
  38. Interdigitating reticulum cells in the human thymus.
    Cell Tissue Res. 1974;155(1):47-55 PMID: 4548659
  39. A pathological study of thymomas.
    Acta Pathol Jpn. 1966 Aug;16(3):323-58 PMID: 6013317
  40. Enzyme histochemical study on human thymus and its age change.
    Acta Pathol Jpn. 1983 Mar;33(2):275-85 PMID: 6306984
  41. Immunologic and ultrastructural characterization of the small cell population in malignant thymoma.
    Hum Pathol. 1983 Apr;14(4):377-80 PMID: 6601048
  42. The human thymic microenvironment: an immunohistologic study.
    J Immunol. 1980 Jul;125(1):202-12 PMID: 6155398
  43. The fine structure of the thymus of the fetal and neonatal monkey (Macaca mulatta).
    Z Zellforsch Mikrosk Anat. 1971;114(2):220-33 PMID: 4994824
  44. Thymomas: clinicopathologic features, therapy, and prognosis.
    Cancer. 1974 Aug;34(2):389-96 PMID: 4855205
  45. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice.
    Am J Anat. 1980 Mar;157(3):227-63 PMID: 7405870
  46. Oat-cell carcinoma of the thymus.
    Cancer. 1982 Apr 15;49(8):1652-7 PMID: 6279270
  47. Tumours of the thymus.
    Ups J Med Sci. 1975;80(3):161-74 PMID: 1243206
  48. Location of T cell and major histocompatibility complex antigens in the human thymus.
    J Exp Med. 1980 Oct 1;152(4):771-82 PMID: 6158549
  49. Ultrastructural studies on erythropoiesis in the avian thymus. I. Description of cell types.
    Cell Tissue Res. 1979 Jun 8;199(1):37-61 PMID: 466697
  50. The fine structure of myoid cells in the human thymus.
    Arch Histol Jpn. 1969 Feb;30(2):207-15 PMID: 5813837
  51. Squamous cell carcinoma of the thymus. An analysis of eight cases.
    Am J Surg Pathol. 1977 Jun;1(2):109-21 PMID: 602973
  52. Thymoma. A clinicopathologic study of 54 cases.
    Am J Surg Pathol. 1979 Jun;3(3):235-49 PMID: 532853
  53. Thymic carcinoma. Five distinctive histological variants.
    Am J Surg Pathol. 1982 Jul;6(5):451-70 PMID: 7125053
  54. Metastasizing thymoma. Report of a case and review of the literature.
    Am J Clin Pathol. 1968 May;49(5):690-6 PMID: 5660964
  55. Thymus cell maturation. Studies on the origin of cortisone-resistant thymic lymphocytes.
    J Exp Med. 1973 Feb 1;137(2):504-10 PMID: 4539848
  56. The fine structure of thymoma, with emphasis on its differential diagnosis. A study of ten cases.
    Am J Pathol. 1975 Oct;81(1):49-86 PMID: 1080957
  57. Ultrastructure of the chick thymus.
    Z Zellforsch Mikrosk Anat. 1973;136(2):191-205 PMID: 4346558
  58. Subpopulations of lymphocytes in human thymomas.
    Clin Exp Immunol. 1979 Sep;37(3):502-6 PMID: 315846
  59. Identification and in situ localization of the "thymic nurse cell" in man.
    J Immunol. 1983 May;130(5):2348-51 PMID: 6601149
Article Info
Journal
Virchows Archiv. A, Pathological anatomy and histopathology
Abbr.
Virchows Arch A Pathol Anat Histopathol
ISSN
0174-7398
DOI
10.1007/BF00737071
Published
1985-00-00
Pages
119-49
Language
English
Region
Germany
NLM ID
8302198
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00737071
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