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PMID: 6336763 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5.

The Journal of clinical investigation ·Vol. 71 ·No. 1 ·1983-01-00 ·Pages 9-14

Haynes BF, Shimizu K, Eisenbarth GS

Abstract

Using a monoclonal antibody (A2B5), which binds to GQ ganglioside, and tetanus toxin, which binds to GD and GT gangliosides, distinct regions of human and rodent thymic epithelial cells have been identified. The lymphoid elements of the thymus do not bind A2B5 or tetanus toxin. The A2B5 and tetanus toxin-binding cells form a network of thymic epithelial cells throughout the thymic subcapsular cortex and thymic medulla and contain thymopoietin and thymosin alpha-1.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Fluorescent Antibody Technique Gangliosides/metabolism Humans Mice Rats Tetanus Toxin/metabolism Thymopoietins/metabolism Thymosin/metabolism Thymus Gland/cytology,metabolism
Chemicals
Antibodies, Monoclonal Gangliosides Tetanus Toxin Thymopoietins Thymosin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Haynes B F
Shimizu K
Eisenbarth G S
References (19)
19 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/jci110755
Published
1983-01-00
Pages
9-14
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC436832
Subset
IM
Grants
NCI NIH HHS · CA 28936 · United States
NCI NIH HHS · K04-CA00695 · United States
External Links
PubMed source DOI: 10.1172/jci110755 PMC Full Text View journal details
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