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PMID: 3905097 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cellular immune response to Mycobacterium bovis (BCG) in genetically-susceptible and resistant congenic mouse strains.

Clinical and experimental immunology ·Vol. 62 ·No. 1 ·1985-10-00 ·Pages 31-8

Bourassa D, Forget A, Pelletier M, Skamene E, Turcotte R

Abstract

Congenic Bcgr (C.D2, resistant) and Bcgs (BALB/c, susceptible) mice were infected intravenously with Mycobacterium bovis (BCG, strain Montreal) in order to establish the relationship between different indicators of the cell-mediated immune response and the bacterial load attained in the host. There was a correlation between the bacterial burden and the splenomegaly response, granuloma formation in the liver and cross-protection against an heterologous pathogen (Listeria monocytogenes) in Bcgr and Bcgs mice. No relationship was found between bacterial load or granuloma formation and the development of specific acquired protection against an homologous organism (BCG or M. tuberculosis, H37Rv) as assessed by the level of resistance attained in BCG-primed mice challenged with virulent H37Rv or by the adoptive immunity conferred by BCG-primed spleen cells transferred to naïve irradiated recipients challenged with BCG.

MeSH Terms
Animals Disease Susceptibility Hypersensitivity, Delayed/immunology Immunity, Cellular Immunity, Innate Immunization, Passive Listeriosis/prevention & control Male Mice Mice, Inbred BALB C Mycobacterium bovis Spleen/microbiology Tuberculin/immunology Tuberculosis/immunology,microbiology,prevention & control
Chemicals
Tuberculin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bourassa D
Forget A
Pelletier M
Skamene E
Turcotte R
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20 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1985-10-00
Pages
31-8
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1577405
Subset
IM
Grants
NIAID NIH HHS · AI18693 · United States
External Links
PubMed source PMC Full Text View journal details
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