Home LiteratureArticle Details
PMID: 3899103 Published · ppublish English Journal Article Review

Collagen genes and inherited connective tissue disease.

The Biochemical journal ·Vol. 229 ·No. 2 ·1985-07-15 ·Pages 287-303

Cheah KS

Abstract

暂无摘要

MeSH Terms
Amino Acids/genetics Animals Chromosome Deletion Collagen/genetics Connective Tissue Diseases/genetics DNA/genetics Female Genes Genetic Linkage Humans Mutation Phenotype Polymorphism, Genetic Pregnancy Prenatal Diagnosis Procollagen/biosynthesis,genetics Tissue Distribution
Chemicals
Amino Acids Procollagen Collagen DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cheah K S
References (128)
128 references, click to expand
  1. Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.
    Proc Natl Acad Sci U S A. 1975 Feb;72(2):586-9 PMID: 1054840
  2. Marfan syndrome. Demonstration of abnormal elastin in aorta.
    J Clin Invest. 1982 Dec;70(6):1245-52 PMID: 7174792
  3. Construction and characterization of type II collagen complementary deoxyribonucleic acid clones.
    Nucleic Acids Res. 1983 Sep 10;11(17):6021-39 PMID: 6310524
  4. Minor collagens of chicken hyaline cartilage.
    Biochemistry. 1981 Sep 15;20(19):5443-8 PMID: 7028104
  5. Collagen: an overview.
    Methods Enzymol. 1982;82 Pt A:3-32 PMID: 7078440
  6. Patients with Ehlers-Danlos syndrome type IV lack type III collagen.
    Proc Natl Acad Sci U S A. 1975 Apr;72(4):1314-6 PMID: 1055406
  7. Genetic heterogeneity of collagens.
    J Invest Dermatol. 1982 Jul;79 Suppl 1:25s-30s PMID: 7086189
  8. Evidence that the collagen in the culture medium of Chinese hamster lung cells contains components related at the primary structural level to the alpha1(V) collagen chain.
    Arch Biochem Biophys. 1984 Mar;229(2):509-18 PMID: 6422858
  9. Lethal osteogenesis imperfecta congenita and a 300 base pair gene deletion for an alpha 1(I)-like collagen.
    Br Med J (Clin Res Ed). 1984 Feb 11;288(6415):431-4 PMID: 6419953
  10. Isolation and characterization of genomic clones corresponding to the human type II procollagen gene.
    Nucleic Acids Res. 1984 Jan 25;12(2):1025-38 PMID: 6320112
  11. Translation of type II procollagen mRNA and hydroxylation of the cell-free product.
    Biochem Biophys Res Commun. 1979 Dec 14;91(3):1025-31 PMID: 526264
  12. A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase.
    J Biol Chem. 1984 Nov 25;259(22):14094-100 PMID: 6438090
  13. Ultrastructural characteristics of the skin in a form of the Ehlers-Danlos syndrome type IV. Storage in the rough endoplasmic reticulum.
    Lab Invest. 1981 Apr;44(4):342-50 PMID: 7193778
  14. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.
    Proc Natl Acad Sci U S A. 1984 Mar;81(5):1504-8 PMID: 6324198
  15. Confirmation that the type I collagen gene on chromosome 17 is COL1A1 (alpha 1(I), using a human genomic probe.
    Ann Hum Genet. 1984 Jan;48(Pt 1):39-42 PMID: 6712154
  16. Detection of single base substitutions in total genomic DNA.
    Nature. 1985 Feb 7-13;313(6002):495-8 PMID: 3969155
  17. The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen.
    J Biol Chem. 1983 Dec 25;258(24):15192-7 PMID: 6418743
  18. Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule.
    J Biol Chem. 1984 Nov 25;259(22):14170-4 PMID: 6501291
  19. Biosynthesis of an unusual collagen type by human astrocytoma cells in vitro.
    J Biol Chem. 1983 Feb 25;258(4):2653-61 PMID: 6401740
  20. Susceptibility of type V collagen to neutral proteases: evidence that the major molecular species is a thrombin-sensitive heteropolymer, [alpha 1(V)]2 alpha 2(V).
    Biochemistry. 1981 Jun 23;20(13):3778-84 PMID: 6791686
  21. Heritable diseases of collagen.
    N Engl J Med. 1984 Aug 9;311(6):376-86 PMID: 6146097
  22. Osteogenesis imperfecta: an expanding panorama of variants.
    Clin Orthop Relat Res. 1981 Sep;(159):11-25 PMID: 7285446
  23. Chain assembly intermediate in the biosynthesis of type III procollagen in chick embryo blood vessels.
    J Biol Chem. 1981 Dec 25;256(24):13193-9 PMID: 6273419
  24. A Hind III restriction site polymorphism in the human collagen alpha 1 (I)-like gene on chromosome No. 7.
    Hum Genet. 1982;62(2):175-6 PMID: 6298096
  25. Collagen evolution.
    Nature. 1981 Jun 11;291(5815):450 PMID: 7231559
  26. Isolation of cDNA and genomic DNA clones encoding type II collagen.
    Nucleic Acids Res. 1984 May 25;12(10):4207-28 PMID: 6203098
  27. Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta.
    Am J Hum Genet. 1984 Nov;36(6):1172-9 PMID: 6097110
  28. Construction and characterization of pro alpha 1 collagen complementary deoxyribonucleic acid clones.
    Biochemistry. 1979 Jul 10;18(14):3146-52 PMID: 380642
  29. Human type I procollagen genes are located on different chromosomes.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6627-30 PMID: 6292910
  30. A 38 base pair insertion in the pro alpha 2(I) collagen gene of a patient with Marfan syndrome.
    J Cell Biochem. 1985;27(2):169-74 PMID: 2985635
  31. Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.
    Nature. 1983 Jul 28-Aug 3;304(5924):315-20 PMID: 6308457
  32. Altered triple helical structure of type I procollagen in lethal perinatal osteogenesis imperfecta.
    J Biol Chem. 1985 Feb 10;260(3):1734-42 PMID: 2981871
  33. Regional localization of the human alpha 2(I) collagen gene on chromosome 7 by molecular hybridization.
    Cytogenet Cell Genet. 1983;35(1):64-6 PMID: 6825474
  34. Formation of the triple helix of type I procollagen in cellulo. A kinetic model based on cis-trans isomerization of peptide bonds.
    Eur J Biochem. 1981 Sep 1;118(3):607-13 PMID: 7297567
  35. Isolation and characterization of new collagens from chick cartilage.
    Eur J Biochem. 1982 May;124(1):57-62 PMID: 7084229
  36. Construction of a cDNA clone corresponding to mouse alpha 1(IV) procollagen.
    Nucleic Acids Res. 1984 Feb 24;12(4):2035-46 PMID: 6546618
  37. Effects of matrix macromolecules on chondrocyte gene expression: synthesis of a low molecular weight collagen species by cells cultured within collagen gels.
    J Cell Biol. 1982 Jun;93(3):767-74 PMID: 6811598
  38. Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.
    J Biol Chem. 1985 Jan 10;260(1):531-6 PMID: 2981217
  39. Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization.
    Am J Hum Genet. 1982 May;34(3):381-7 PMID: 6282119
  40. Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII.
    J Biol Chem. 1980 Sep 25;255(18):8887-93 PMID: 6773953
  41. Identification of a Balb/c mouse pro alpha 1(I) procollagen gene: evidence for insertions or deletions in gene coding sequences.
    DNA. 1981;1(1):59-69 PMID: 6219867
  42. A repetitive structure in the chick alpha 2-collagen gene.
    Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:777-83 PMID: 6942950
  43. Type I osteogenesis imperfecta: a nonfunctional allele for pro alpha 1 (I) chains of type I procollagen.
    Proc Natl Acad Sci U S A. 1982 Jun;79(12):3838-42 PMID: 6954526
  44. Isolation of cDNA clones for basal lamina components: type IV procollagen.
    Nucleic Acids Res. 1983 Sep 24;11(18):6199-209 PMID: 6312413
  45. Abnormal type I collagen metabolism by cultured fibroblasts in lethal perinatal osteogenesis imperfecta.
    Biochem J. 1984 Jan 1;217(1):103-15 PMID: 6421277
  46. Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.
    Nature. 1982 Apr 15;296(5858):627-31 PMID: 6280057
  47. Human pro alpha 1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons.
    Nature. 1984 Jul 26-Aug 1;310(5975):337-40 PMID: 6462220
  48. Identification and partial characterization of three low-molecular-weight collagenous polypeptides synthesized by chondrocytes cultured within collagen gels in the absence and in the presence of fibronectin.
    Biochem J. 1983 May 1;211(2):417-26 PMID: 6870839
  49. Construction and characterization of a 2.5-kilobase procollagen clone.
    Proc Natl Acad Sci U S A. 1978 Nov;75(11):5417-21 PMID: 364479
  50. Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases.
    J Biol Chem. 1985 Feb 10;260(3):1937-44 PMID: 2981879
  51. Prenatal diagnosis of a severe deforming type of osteogenesis imperfecta.
    Am J Med Genet. 1984 Dec;19(4):707-14 PMID: 6393765
  52. DNA and chromatin structure of the human alpha 1 (I) collagen gene.
    J Biol Chem. 1984 Dec 10;259(23):14906-13 PMID: 6094581
  53. Human cartilage collagens. Comparison of cartilage collagens with human type V collagen.
    J Biol Chem. 1982 Jul 10;257(13):7852-6 PMID: 7085652
  54. Identification of genomic DNA coding for chicken type II procollagen.
    J Biol Chem. 1983 Oct 10;258(19):11617-21 PMID: 6311817
  55. Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.
    J Biol Chem. 1980 Mar 25;255(6):2612-5 PMID: 6244285
  56. Type X collagen, a product of hypertrophic chondrocytes.
    Biochem J. 1985 Apr 15;227(2):545-54 PMID: 4004779
  57. Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta.
    J Biol Chem. 1983 Jun 25;258(12):7721-8 PMID: 6863261
  58. Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide.
    J Biol Chem. 1984 Jun 25;259(12):7826-34 PMID: 6330084
  59. Marfan syndrome: abnormal alpha 2 chain in type I collagen.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7745-9 PMID: 6950413
  60. Ehlers-Danlos syndrome IV due to a novel defect in type III procollagen.
    Am J Med Genet. 1984 Nov;19(3):607-22 PMID: 6507506
  61. A new method for detection of small modifications in genomic DNA, applied to the human delta-beta globin gene cluster.
    Eur J Biochem. 1984 Aug 1;142(3):473-80 PMID: 6088226
  62. Clinical and ultrastructural heterogeneity of type IV Ehlers-Danlos syndrome.
    Hum Genet. 1979 Mar 12;47(2):141-50 PMID: 437782
  63. DNA sequence comparison of the regulatory signals at the 5' end of the mouse and chick alpha 2 type I collagen genes.
    J Biol Chem. 1984 Jun 25;259(12):7411-5 PMID: 6203894
  64. Prenatal diagnosis of lethal perinatal osteogenesis imperfecta (OI type II).
    J Pediatr. 1982 Jan;100(1):127-33 PMID: 7057300
  65. Monoclonal antibodies against chicken type IV and V collagens: electron microscopic mapping of the epitopes after rotary shadowing.
    J Cell Biol. 1984 May;98(5):1637-44 PMID: 6202698
  66. Structural abnormalities in the dermal collagen and elastic matrix from the skin of patients with inherited connective tissue disorders.
    J Invest Dermatol. 1982 Jul;79 Suppl 1:7s-16s PMID: 6806400
  67. Osteonectin, a bone-specific protein linking mineral to collagen.
    Cell. 1981 Oct;26(1 Pt 1):99-105 PMID: 7034958
  68. Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2213-7 PMID: 6585794
  69. Structural diversity and domain composition of a unique collagenous fragment (intima collagen) obtained from human placenta.
    Biochem J. 1983 May 1;211(2):295-302 PMID: 6870834
  70. Reduced secretion of structurally abnormal type I procollagen in a form of osteogenesis imperfecta.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):5142-6 PMID: 6946461
  71. Molecular cloning and carboxyl-propeptide analysis of human type III procollagen.
    Nucleic Acids Res. 1984 Dec 21;12(24):9383-94 PMID: 6096827
  72. Electron-microscopical approach to a structural model of intima collagen.
    Biochem J. 1983 May 1;211(2):303-11 PMID: 6307276
  73. The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp.
    Cell. 1980 Dec;22(3):887-92 PMID: 7460017
  74. Isolation and characterization of a genomic clone encoding chick alpha 1 type III collagen.
    J Biol Chem. 1983 Mar 10;258(5):2758-61 PMID: 6298201
  75. Construction and identification of a cDNA clone for human type II procollagen mRNA.
    Biochem J. 1985 Jul 1;229(1):183-8 PMID: 3840017
  76. Synthesis and characterization of cDNA encoding a cartilage-specific short collagen.
    Proc Natl Acad Sci U S A. 1984 May;81(10):3014-8 PMID: 6328487
  77. A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):6179-83 PMID: 6934545
  78. Evidence for a dose-dependent inflammatory response to quartz in the rat lung and its significance in early changes in collagen metabolism.
    Environ Health Perspect. 1983 Sep;51:141-6 PMID: 6315354
  79. Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3516-20 PMID: 6267597
  80. Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence.
    Proc Natl Acad Sci U S A. 1978 Dec;75(12):5846-50 PMID: 366605
  81. A new form of Ehlers-Danlos syndrome. Fibronectin corrects defective platelet function.
    JAMA. 1980 Jul 11;244(2):144-7 PMID: 7382073
  82. Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D.
    Biochemistry. 1984 Dec 4;23(25):6210-6 PMID: 6395893
  83. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy.
    Nature. 1982 Nov 4;300(5887):69-71 PMID: 6982420
  84. The biosynthesis of procollagen.
    Essays Biochem. 1976;12:77-113 PMID: 188639
  85. Isolation of cDNA clones specific for collagen IV and laminin from mouse teratocarcinoma cells.
    Proc Natl Acad Sci U S A. 1983 Oct;80(19):5880-4 PMID: 6310600
  86. Matrix sialoprotein of developing bone.
    J Biol Chem. 1983 Oct 25;258(20):12723-7 PMID: 6355090
  87. Isolation and characterization of a human pro alpha 2(I) collagen gene segment.
    J Invest Dermatol. 1984 Mar;82(3):265-9 PMID: 6321602
  88. Altered relation of two collagen types in osteogenesis imperfecta.
    N Engl J Med. 1977 May 26;296(21):1200-3 PMID: 857159
  89. Bibliography of cloned human and other selected DNAs.
    Am J Hum Genet. 1984 Jan;36(1):235-51 PMID: 17948562
  90. Isolation and characterization of a cDNA clone for the amino-terminal portion of the pro-alpha 1(II) chain of cartilage collagen.
    J Biol Chem. 1984 Nov 25;259(22):13668-73 PMID: 6094525
  91. Proteoglycans of developing bone.
    J Biol Chem. 1983 May 25;258(10):6588-94 PMID: 6189828
  92. Multiexon deletion in an osteogenesis imperfecta variant with increased type III collagen mRNA.
    J Biol Chem. 1985 Jan 25;260(2):691-4 PMID: 2981843
  93. Conservation of the sizes for one but not another class of exons in two chick collagen genes.
    Nature. 1984 Jul 26-Aug 1;310(5975):333-7 PMID: 6547770
  94. Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation.
    J Biol Chem. 1984 Nov 10;259(21):12941-4 PMID: 6092353
  95. Collagen heterogeneity in human cartilage: identification of several new collagen chains.
    Biochem Biophys Res Commun. 1979 Apr 27;87(4):1124-31 PMID: 465027
  96. Cysteine in the triple-helical domain of one allelic product of the alpha 1(I) gene of type I collagen produces a lethal form of osteogenesis imperfecta.
    J Biol Chem. 1984 Sep 10;259(17):11129-38 PMID: 6469997
  97. Analysis of the 3' end of the human pro-alpha 2(I) collagen gene. Utilization of multiple polyadenylation sites in cultured fibroblasts.
    J Biol Chem. 1983 Aug 25;258(16):10128-35 PMID: 6309769
  98. Structurally distinct collagen types.
    Annu Rev Biochem. 1980;49:957-1003 PMID: 6157354
  99. Biochemical heterogeneity of osteogenesis imperfecta: New variant.
    Lancet. 1979 Jun 2;1(8127):1193 PMID: 86915
  100. Copy number of a human type I alpha 2 collagen gene.
    J Biol Chem. 1982 Nov 25;257(22):13816-22 PMID: 6292209
  101. A unique low molecular weight collagen secreted by cultured chick embryo chondrocytes.
    J Biol Chem. 1982 Oct 25;257(20):12444-50 PMID: 7118948
  102. Structure of the pro alpha 2 (I) collagen gene.
    Nature. 1981 Nov 12;294(5837):129-35 PMID: 6272119
  103. Chinese hamster lung cells synthesize and confine to the cellular domain a collagen composed solely of B chains.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5206-10 PMID: 7001474
  104. Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta.
    Proc Natl Acad Sci U S A. 1984 Jul;81(14):4524-8 PMID: 6087329
  105. Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta.
    Nature. 1983 Jul 7-13;304(5921):78-80 PMID: 6191221
  106. Identification and characterization of the human type II collagen gene (COL2A1).
    Proc Natl Acad Sci U S A. 1985 May;82(9):2555-9 PMID: 3857598
  107. Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta.
    J Biol Chem. 1983 May 10;258(9):5915-21 PMID: 6304100
  108. Comparisons of the complete sequences of two collagen genes from Caenorhabditis elegans.
    Cell. 1982 Sep;30(2):599-606 PMID: 7139711
  109. Biosynthesis of procollagen.
    Annu Rev Biochem. 1978;47:129-62 PMID: 354493
  110. An abnormal collagen alpha chain containing cysteine in autosomal dominant osteogenesis imperfecta.
    Br Med J (Clin Res Ed). 1984 Jan 14;288(6411):112-3 PMID: 6419811
  111. Abnormal alpha 2-chain in type I collagen from a patient with a form of osteogenesis imperfecta.
    J Clin Invest. 1983 Mar;71(3):689-97 PMID: 6826730
  112. Biosynthetic and structural properties of endothelial cell type VIII collagen.
    J Biol Chem. 1983 Nov 10;258(21):13391-401 PMID: 6630235
  113. DNA markers for nervous system diseases.
    Science. 1984 Sep 21;225(4668):1320-6 PMID: 6089346
  114. Osteogenesis imperfecta (lethal) bones contain types III and V collagens.
    J Clin Pathol. 1980 Jun;33(6):534-8 PMID: 7400355
  115. The structure of type IX collagen.
    J Biol Chem. 1985 Jan 10;260(1):220-5 PMID: 2981204
  116. Collagen genes and brittle bones.
    Ann Intern Med. 1983 Nov;99(5):700-4 PMID: 6638727
  117. Expression and novel structure of a collagen gene in Drosophila.
    Proc Natl Acad Sci U S A. 1982 Mar;79(6):1761-5 PMID: 6210912
  118. Identification of a new disulphide bonded collagen from cartilage.
    FEBS Lett. 1980 Nov 17;121(1):51-4 PMID: 7461120
  119. Ehlers-Danlos syndrome type IV D: an autosomal recessive disorder.
    Clin Genet. 1984 Mar;25(3):278-87 PMID: 6705261
  120. Glycosaminoglycans and their binding to biological macromolecules.
    Annu Rev Biochem. 1978;47:385-417 PMID: 354500
  121. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.
    J Clin Invest. 1983 Oct;72(4):1262-7 PMID: 6313757
  122. The structure of collagen genes.
    Int Rev Connect Tissue Res. 1983;10:1-63 PMID: 6315622
  123. Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death.
    Cell. 1984 Sep;38(2):597-607 PMID: 6467375
  124. The genetics of blood coagulation.
    Adv Hum Genet. 1983;13:1-81 PMID: 6362359
  125. Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain.
    Nucleic Acids Res. 1982 Oct 11;10(19):5925-34 PMID: 6183642
  126. Characterization of a type IV procollagen synthesized by human amniotic fluid cells in culture.
    J Biol Chem. 1979 May 25;254(10):4197-204 PMID: 438183
  127. Structural organization of a 17 KB segment of the alpha 2 collagen gene: evaluation by R loop mapping.
    Nucleic Acids Res. 1980 May 24;8(10):2241-53 PMID: 7433091
  128. Biochemical and immunological studies of fibroblasts derived from a patient with Ehlers-Danlos syndrome type IV. Demonstrate reduced type III collagen synthesis.
    Arch Dermatol Res. 1980;269(2):169-77 PMID: 7458408
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2290287
Published
1985-07-15
Pages
287-303
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1145061
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2290287 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2